Details of the Drug Formulation (DFM)
| General Information of DFM (ID: F10065) | |||||
|---|---|---|---|---|---|
| Name |
Ibandronic acid 150 mg tablet
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| Company |
Alvogen
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| Active Pharmaceutical Ingredient (API) | Ibandronic acid |
API Info
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| Osteoporosis | ICD-11: FB83 | Approved | |||
| Drug Inactive Ingredient (DIGs) | |||||
| DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
| E0PE9M | DIG Info | Crospovidone | Disintegrant | ||
| E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
| E00DHW | DIG Info | Lactose monohydrate | Binding agent ... | ||
| E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
| E0RS6F | DIG Info | Sodium stearyl fumarate | lubricant | ||
| E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
| E0H2SC | DIG Info | Water | Solvent | ||
| Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
|---|---|---|---|---|---|---|
| Oxidoreductase (ORase) | ||||||
| DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Crospovidone | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Silicon dioxide | |||||
| Biological Activity | Protein expression downregulation (tested by experiment) | [1] | ||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CP3A4_HUMAN | |||||
| Cell line (CELL) | ||||||
| DBT Name: Leukemia K562 cells (K562) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Sodium stearyl fumarate | |||||
| Biological Activity | IC50 = 20.2 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) | [2] | ||||
| Structural Similarity | Tanimoto coefficient = 0.75 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| Cellosaurus ID | CVCL_0004 | |||||
| DBT Name: Breast cancer MCF7 cells (MCF7) | Click to Show/Hide | |||||
| Detailed Information |
DBT Info
click to show the detail info of this DBT
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| Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
| Interacting DIG | Sodium stearyl fumarate | |||||
| Biological Activity | IC50 = 60 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) | [2] | ||||
| Structural Similarity | Tanimoto coefficient = 0.75 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| Cellosaurus ID | CVCL_0031 | |||||
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