Details of the Drug Formulation (DFM)
General Information of DFM (ID: F13052) | |||||
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Name |
Mesalamine 375 mg capsule
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Company |
Aphena Pharma Solutions-Tennessee; Salix Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Mesalamine | API Info click to show the detail info of this API | |||
Inflammatory bowel disease | ICD-11: DD72 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0BI3X | DIG Info | Aspartame | Flavoring agent | ||
E0F6AN | DIG Info | Kyselina citronova | Acidulant ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
E0K0OU | DIG Info | Triethyl citrate | Plasticizing agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: N1-methyl adenine demethylase (FTO) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 300000 nM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | FTO_HUMAN | |||||
DBT Name: RNA demethylase ALKBH5 (ALKB5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 488000 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ALKB5_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Silicon dioxide | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Matrix metalloproteinase-1 (MMP1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Aspartame | |||||
Biological Activity | IC50 = 20000 nM (estimated based on the structural similarity with CHEMBL62186 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.916666667 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MMP1_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Factor HNF-4-alpha (HNF4A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 39869 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | HNF4A_HUMAN | |||||
DBT Name: Pregnane X receptor (NR1I2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Aspartame | |||||
Biological Activity | Ki = 13 uM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NR1I2_HUMAN | |||||
Other protein families (OPF) | ||||||
DBT Name: Perilipin-1 (PLIN1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 3708 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PLIN1_HUMAN | |||||
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