General Information of DFM (ID: F15374)
Name	Nilutamide 150 mg tablet
Company	ANI Pharmaceuticals
Active Pharmaceutical Ingredient (API)	Nilutamide		API Info click to show the detail info of this API
	Prostate cancer		ICD-11: 2C82	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0F2PK	DIG Info	Calcium stearate	lubricant
	E0FH4N	DIG Info	Docusate sodium	Surfactant
	E00DHW	DIG Info	Lactose monohydrate	Binding agent ...
	E0QY1F	DIG Info	Talc	Anticaking agent ...
	E0FU1S	DIG Info	Vinylpyrrolidone	Binding agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	IC50 = 65 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
DBT Name: Cytochrome P450 2E1 (CYP2E1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	EC50 = 141.8 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
DBT Name: Cytochrome P450 2C9 (CYP2C9)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	EC50 = 203.3 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2C9_HUMAN
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	IC50 = 372 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2CJ_HUMAN
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	IC50 = 95.5 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2D6_HUMAN
DBT Name: Cytochrome P450 3A5 (CYP3A5)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	EC50 = 195.8 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A5_HUMAN
Hydrolase (HDase)
DBT Name: Histone deacetylase (HDAC)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	IC50 = 9600 nM (estimated based on the structural similarity with CHEMBL271677 )					[2]
Structural Similarity	Tanimoto coefficient = 0.824561404
Tested Species	Homo sapiens (Human)
UniProt ID	HDAC1_HUMAN ; HDAC2_HUMAN ; HDAC3_HUMAN ; HDAC4_HUMAN ; HDAC5_HUMAN ; HDAC6_HUMAN ; HDAC7_HUMAN ; HDAC8_HUMAN ; HDAC9_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Cholesterol 25-hydroxylase (CYP1A2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	EC50 = 147.4 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP1A2_HUMAN
Potential-driven transporter (PDT)
DBT Name: Solute carrier SLCO2B1 (OATPB)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	Inhibition ratio = 87.8 % (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	Ki = 2.76 uM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	Ki = 2.3 uM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	SO2B1_HUMAN
Cell line (CELL)
DBT Name: Lung cancer A-549 cells (A-549)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Docusate sodium
Biological Activity	IC50 = 154000 nM (estimated based on the structural similarity with CHEMBL271677 )					[2]
Structural Similarity	Tanimoto coefficient = 0.824561404
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0023

References
1	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2	New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):1893-7.
3	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.

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