Details of the Drug Inactive Ingredient (DIG)
General Information of DIG (ID: E0CX3L) | |||||
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DIG Name |
Polyoxyl 35 castor oil
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DIG Function |
Emulsifying agent; Solubilizing agent; Surfactant
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Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG | ||||||
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ICD Disease Classification 01 | Infectious/parasitic disease | Click to Show/Hide | ||||
Ritonavir
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API Info |
Human immunodeficiency virus infection [ICD-11: 1C60]
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[1] | |||
ICD Disease Classification 05 | Endocrine/nutritional/metabolic disease | Click to Show/Hide | ||||
Pravastatin
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API Info |
Dyslipidaemia [ICD-11: 5C81]
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[2] | |||
Paricalcitol
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API Info |
Hyperparathyroidism [ICD-11: 5A51]
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[3] | |||
ICD Disease Classification 10 | Ear/mastoid process disease | Click to Show/Hide | ||||
Amoxicillin
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API Info |
Acute otitis media [ICD-11: AB00]
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[4] | |||
ICD Disease Classification 15 | Musculoskeletal/connective-tissue disease | Click to Show/Hide | ||||
Cyclosporin A
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API Info |
Rheumatoid arthritis [ICD-11: FA20]
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[5] | |||
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Cytochrome P450 3A (CYP3A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 250 uM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN ; CP3A5_HUMAN ; CP3A7_HUMAN ; CP343_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN ; CP3A5_HUMAN ; CP3A7_HUMAN ; CP343_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 306.5 uM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 600 uM (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
DBT Name: Cytochrome P450 2E1 (CYP2E1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 113.3 uM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2E1_HUMAN | |||||
DBT Name: Cytochrome P450 2C9 (CYP2C9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 41.1 uM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2C9_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 30 uM (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2C9_HUMAN | |||||
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 36.1 uM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2CJ_HUMAN | |||||
DBT Name: Cytochrome P450 3A5 (CYP3A5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 10.1 uM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A5_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | EC50 = 1.1 uM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 2 (ABCC2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio = 51 % (tested by experiment) | [10] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio > 73 % (tested by experiment) | [11] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 5 mg.mL-1 (tested by experiment) | [12] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio = 61 % (tested by experiment) | [13] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio > 100 % (tested by experiment) | [14] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
DBT Name: Urate exporter (BCRP) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Inhibition ratio > 40 % (tested by experiment) | [14] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ABCG2_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Solute carrier SLCO1B1 (OATP-C) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.19 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1B1_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.3 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1B1_HUMAN | |||||
DBT Name: Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.0011 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.0098 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
DBT Name: Solute carrier SLCO1A2 (OATP-A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.00054 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1A2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.00034 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1A2_HUMAN | |||||
DBT Name: Organic anion transporter 8 (OAT8) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.001 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1B3_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.0047 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1B3_HUMAN | |||||
DBT Name: Sodium/bile acid cotransporter (SLC10A1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 2.8 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NTCP_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | IC50 = 0.012 %(w/v) (tested by experiment) | [15] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NTCP_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Colon cancer Caco-2 cells (Caco-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Biological Activity | Chylomicron secretion downregulation (tested by experiment) | [16] | ||||
Tested Species | Homo sapiens (Human) | |||||
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