Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00668)
Name
Tetracycline
Synonyms    Click to Show/Hide the Synonyms of This API
tetracycline; 60-54-8; Tetracyclinum; Achromycin; Tetracyclin; Deschlorobiomycin; Sumycin; Abramycin; Tsiklomitsin; Achromycin V; Liquamycin; Panmycin; Tetracyn; Tetrazyklin; Ambramycin; Hostacyclin; Omegamycin; Tetradecin; Tetraverine; Tsiklomistsin; Vetacyclinum; Tetrafil; Tetracycline base; Cefracycline; Criseociclina; Abricycline; Agromicina; Ambramicina; Biocycline; Ciclibion; Copharlan; Democracin; Lexacycline; Limecycline; Mericycline; Micycline; Orlycycline; Polycycline; Polyotic; Purocyclina; Roviciclina; Solvocin; Tetrabon; Tetracycl; Amycin; Veracin; SK-Tetracycline; Tetracycline II; Tetra-Co; UNII-F8VB5M810T; Cyclomycin; Sustamycin; Tetrex; Sumycin syrup; Tetracycline I; Bio-tetra; CHEBI:27902; Piracaps (base); Centet (base); Polycycline (VAN); Cefracycline suspension; Liquamycin (Veterinary); Polycycline (antibiotic); F8VB5M810T; Tetraciclina; Tetracycline (internal use); Supramycin; Vetquamycin-324 (free base); MFCD00151232; 60-54-8 (FREE BASE); NSC-108579; Achromycin (naphthacene derivative); NSC 108579; HSDB 3188; 6-Methyl-1,11-dioxy-2-naphthacenecarboxamide; Tetracyclinum [INN-Latin]; Tetraciclina [INN-Spanish]; Sumycin (TN); 6416-04-2 (3H2O); Economycin; Vetquamycin; Brodspec; Tetracycline (JAN/USP/INN); CCRIS 9483; SR-01000000212; NSC108579; Tetrabid Organon; Ala-Tet; Tetracycline [USP:INN:BAN:JAN]; EINECS 200-481-9; Spectrum_001034; Tetracycline, EP grade; Prestwick0_000140; Prestwick1_000140; Prestwick2_000140; Prestwick3_000140; Spectrum2_001329; Spectrum3_000565; Spectrum4_000352; Spectrum5_001112; DSSTox_CID_3645; EC 200-481-9; SCHEMBL3098; DSSTox_RID_77127; DSSTox_GSID_23645; BSPBio_000220; BSPBio_001950; KBioGR_000783; KBioSS_001514; BIDD:GT0653; DivK1c_000827; SCHEMBL537050; SPBio_001457; SPBio_002159; BPBio1_000242; SCHEMBL2116649; SCHEMBL2116661; DTXSID7023645; SCHEMBL21271987; GTPL10927; KBio1_000827; KBio2_001514; KBio2_004082; KBio2_006650; KBio3_001450; NINDS_000827; HMS2090B04; Tetracycline, >=98.0% (NT); HY-A0107; RKL10088; Tetracycline, >=88.0% (HPLC); Tox21_300150; BDBM50237605; ZINC84441937; AKOS024277860; AKOS026749977; ZINC100303069; ZINC102229720; CS-8188; DB00759; MCULE-3752961261; CAS-60-54-8; IDI1_000827; NCGC00017323-03; NCGC00017323-04; NCGC00017323-05; NCGC00017323-07; NCGC00017323-15; NCGC00142507-02; NCGC00254063-01; ST019403; SBI-0051530.P003; 1369-EP2269978A2; 1369-EP2269985A2; 1369-EP2269991A2; 1369-EP2270008A1; 1369-EP2275420A1; 1369-EP2284150A2; 1369-EP2284151A2; 1369-EP2284152A2; 1369-EP2284153A2; 1369-EP2284155A2; 1369-EP2284156A2; 1369-EP2284164A2; 1369-EP2287140A2; 1369-EP2287148A2; 1369-EP2287150A2; 1369-EP2289871A1; 1369-EP2289891A2; 1369-EP2292088A1; 1369-EP2292590A2; 1369-EP2292612A2; 1369-EP2292617A1; 1369-EP2295402A2; 1369-EP2295419A2; 1369-EP2298732A1; 1369-EP2301534A1; 1369-EP2301912A2; 1369-EP2301913A1; 1369-EP2301914A1; 1369-EP2301916A2; 1369-EP2305637A2; 1369-EP2305640A2; 1369-EP2305662A1; 1369-EP2307027A1; 1369-EP2308832A1; 1369-EP2308863A1; 1369-EP2308883A1; 1369-EP2311451A1; 1369-EP2311796A1; 1369-EP2311797A1; 1369-EP2311798A1; 1369-EP2311799A1; 1369-EP2311822A1; 1369-EP2314583A1; 1369-EP2316450A1; 1369-EP2371797A1; 1369-EP2371798A1; 1369-EP2371800A1; 1369-EP2371804A1; C06570; D00201; AB00053550-04; AB00053550_05; AB00053550_06; Q193045; SR-01000000212-3; Z2144222809
Clinical Status
Approved
Disease Indication Spotted fever ICD-11: 1C31 [1]
PubChem CID
54675776
Formula
C22H24N2O8
Canonical SMILES
C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
InChI
1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
InChIKey
NWXMGUDVXFXRIG-WESIUVDSSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=54675776"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 444.4 Topological Polar Surface Area 182
XlogP -2 Complexity 971
Heavy Atom Count 32 Rotatable Bond Count 2
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Full List of Drug Formulations (DFMs) Containing This API
          Tetracycline 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 22; Lactose; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; D&c yellow no. 10; Fd&c red no. 40; Benzyl alcohol; Butyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Propylparaben; Sodium propionate; Edetate calcium disodium; Ethylene glycol monoethyl ether; Ferrosoferric oxide; Titanium dioxide; Water; Lecithin, soybean; Silicon dioxide; Alcohol; Aluminum oxide; Dimethicone; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Watson Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 22 DIG Info Organic anion transporter 1 (Ki = 89.13 nM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [5]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [6]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [7]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 22; Lactose; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; Fd&c red no. 40; Benzyl alcohol; Butyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Propylparaben; Sodium propionate; Edetate calcium disodium; Ethylene glycol monoethyl ether; Ferrosoferric oxide; Titanium dioxide; Water; Lecithin, soybean; Silicon dioxide; Alcohol; Aluminum oxide; Dimethicone; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 22 DIG Info Organic anion transporter 1 (Ki = 89.13 nM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [5]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [6]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [7]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin, unspecified
                   Dosage Form Oral Capsule
                   Company Alvogen; Chartwell RX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Silicon dioxide; Gelatin; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company PD-Rx Pharmaceuticals; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Silicon dioxide; Aluminum oxide; Gelatin; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company IVAX Pharmaceuticals; Liberty Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Propylene glycol; Titanium dioxide; Gelatin; Light mineral oil; Shellac
                   Dosage Form Oral Capsule
                   Company AvKARE; Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c yellow no. 6; Titanium dioxide; Silicon dioxide; Starch, corn
                   Dosage Form Oral Capsule
                   Company Bryant Ranch Prepack; Physicians Total Care; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c yellow no. 6; Titanium dioxide; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Capsule
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate
                   Dosage Form Oral Capsule
                   Company Harris Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
          Tetracycline 500 mg capsule Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; Fd&c red no. 40; Benzyl alcohol; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Propylparaben; Sodium propionate; Edetate calcium disodium; Ethylene glycol monoethyl ether; Titanium dioxide; Water; Lecithin, soybean; Silicon dioxide; Alcohol; Dimethicone; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Bryant Ranch Prepack; Watson Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [5]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [6]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [7]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; Fd&c red no. 40; Benzyl alcohol; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Propylparaben; Sodium propionate; Edetate calcium disodium; Ethylene glycol monoethyl ether; Titanium dioxide; Water; Lecithin, soybean; Alcohol; Colloidal silicon dioxide; Dimethicone; Gelatin; Shellac
                   Dosage Form Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [5]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [6]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [7]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [4]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [9]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin, unspecified
                   Dosage Form Oral Capsule
                   Company Alvogen; Chartwell RX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Magnesium stearate; Propylene glycol; Titanium dioxide; Gelatin; Light mineral oil; Shellac
                   Dosage Form Oral Capsule
                   Company AvKARE; Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [4]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Ammonia; Propylene glycol; Titanium dioxide; Silicon dioxide; Gelatin; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company H. J. Harkins Company; PD-Rx Pharmaceuticals; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Ammonia; Propylene glycol; Titanium dioxide; Silicon dioxide; Dimethicone; Gelatin; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company IVAX Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Titanium dioxide; Silicon dioxide; Starch, corn
                   Dosage Form Oral Capsule
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Titanium dioxide; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Capsule
                   Company Blenheim Phamacal; Contract Pharmacal; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [4]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [4]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate
                   Dosage Form Oral Capsule
                   Company Harris Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [8]
References
1 FDA label for approved tetracycline from the official website of the U.S. Food and Drug Administration.
2 Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
5 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.
6 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
7 Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution. ACS Med Chem Lett. 2017 Dec 15; 9(1):51-55.
8 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
9 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.