Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00499)
Name
Oxazepam
Synonyms    Click to Show/Hide the Synonyms of This API
oxazepam; Tazepam; Adumbran; 604-75-1; Droxacepam; Ansioxacepam; Anxiolit; Durazepam; Nesontil; Noctazepam; Praxiten; Psiquiwas; Quilibrex; Aplakil; Astress; Bonare; Drimuel; Isodin; Limbial; Murelax; Pacienx; Propax; Rondar; Sedigoa; Serenal; Serenid; Serepax; Seresta; Serpax; Sobril; Zaxopam; Hi-Long; Azutranquil; Nortemazepam; Psicopax; Sigacalm; (RS)-Oxazepam; Nozepam; Tarchomin; (+-)-Oxazepam; Serenid-D; Lederpam; Oxazepamum; Oxozepam; Oxanid; Tacepam; Tranquo-buscopan-wirkstoff; Oxa-puren; Z10-Tr; WY-3498; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-; Ro 5-6789; CB 8092; 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one; 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one; CHEBI:7823; Abboxapam; Alepam; Anxiolit retard; NSC-169448; N-Desmethyltemazepam; Ossazepam [DCIT]; NCGC00159323-02; NCGC00159323-03; Ossazepam; Oxazipam; DSSTox_CID_1087; Oxazepamum [INN-Latin]; DSSTox_RID_75934; DSSTox_GSID_21087; Z 10 tr; Wy 3498; CAS-604-75-1; CCRIS 488; Serax (TN); HSDB 3140; EINECS 210-076-9; NSC 169448; Oxazepam (JAN/USP/INN); Oxazepam civ; DEA No. 2835; 1,3-Dihydro-7-chloro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-Hydroxynordiazepam; Oxazepam [USAN:USP:INN:BAN:JAN]; (.+/-.)-Oxazepam; CHEMBL568; (+-)-7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one; Oprea1_501459; SCHEMBL27435; Temazepam impurity, oxazepam-; DivK1c_000986; GTPL7253; DTXSID1021087; NIOSH/DF2371850; ADIMAYPTOBDMTL-UHFFFAOYSA-; BDBM85031; HMS503E13; KBio1_000986; Oxazepam 0.1 mg/ml in Methanol; Oxazepam 1.0 mg/ml in Methanol; NINDS_000986; NSC_4616; Tox21_111572; Tox21_112819; Tox21_200700; Tox21_303501; 1,3-Dihydro-7-chloro-3-hydroxy-5-phenyl-3H-1,4-benzodiazepin-2-one; 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepine-2-one; 7-Chloro-1,4-benzodiazepine-2-one; MFCD00057903; NSC169448; AKOS016347293; DB00842; J3.308A; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-, (+-)-; IDI1_000986; WLN: T67 GMV JN IHJ CG IQ KR; NCGC00159323-04; NCGC00257352-01; NCGC00258254-01; CAS_604-75-1; DF23718500; C07359; D00464; 604O751; Q412299; SR-01000942251; 2H-1, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-; 7-chloro-5-phenyl-3H-1,4-benzodiazepine-2,3-diol; SR-01000942251-1; 7-Chloro-3-hydroxy-5-phenyl-1,4-benzodiazepin-2-one; Oxazepam solution, drug standard, 1.0 mg/mL in methanol; Oxazepam, European Pharmacopoeia (EP) Reference Standard; 3-hydroxy-1,3-dihydro-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one; 3-hydroxy-5-phenyl-7-chloro-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 3H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-3-hydroxy-5-phenyl-; 7-Chloro-1,3-dihydro-3-hydroxy-5-phenyl-1,4 [2Hl-benzodiazepin-2-one; 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 7-chloro-3-hydroxy-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; 7-CHLORO-3-HYDROXY-5-PHENYL-1,3-DIHYDRO-2H-BENZO[E][1,4]DIAZEPIN-2-ONE; Oxazepam for peak identification, European Pharmacopoeia (EP) Reference Standard
Clinical Status
Approved
Disease Indication Anxiety disorder ICD-11: 6B00 [1]
PubChem CID
4616
Formula
C15H11ClN2O2
Canonical SMILES
C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O
InChI
1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
InChIKey
ADIMAYPTOBDMTL-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4616"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 286.71 Topological Polar Surface Area 61.7
XlogP 2.2 Complexity 407
Heavy Atom Count 20 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Oxazepam 30 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Propylparaben; Titanium dioxide; Croscarmellose sodium; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Aphena Pharma Solutions-Tennessee; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Propylparaben; Titanium dioxide; Croscarmellose sodium; Gelatin, unspecified; Hypromellose, unspecified; Starch, corn
                   Dosage Form Oral Capsule
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; D&c red no. 7; Fd&c blue no. 2; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company Aphena Pharma Solutions-Tennessee; Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Oxazepam 10 mg capsule Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium lauryl sulfate; Butylparaben; Benzyl alcohol; D&c red no. 7; Magnesium stearate; Propylparaben; Sodium propionate; Edetate calcium disodium; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company Aphena Pharma Solutions-Tennessee; Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [6]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [7]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium lauryl sulfate; Butylparaben; Benzyl alcohol; D&c red no. 7; Magnesium stearate; Propylparaben; Sodium propionate; Edetate calcium disodium; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [6]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [7]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; Fd&c red no. 40; Magnesium stearate; Propylparaben; Titanium dioxide; Croscarmellose sodium; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Aphena Pharma Solutions-Tennessee; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; Fd&c red no. 40; Magnesium stearate; Propylparaben; Titanium dioxide; Croscarmellose sodium; Gelatin, unspecified; Hypromellose, unspecified; Starch, corn
                   Dosage Form Oral Capsule
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
          Oxazepam 15 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Magnesium stearate; Propylparaben; Titanium dioxide; Croscarmellose sodium; Gelatin; Hypromelloses; Starch, corn
                   Dosage Form Oral Capsule
                   Company Actavis Pharma; Aphena Pharma Solutions-Tennessee; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Magnesium stearate; Propylparaben; Titanium dioxide; Croscarmellose sodium; Gelatin, unspecified; Hypromellose, unspecified; Starch, corn
                   Dosage Form Oral Capsule
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [4]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; D&c red no. 7; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company Aphena Pharma Solutions-Tennessee; Avera McKennan Hospital; RemedyRepack; Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved oxazepam from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
7 Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution. ACS Med Chem Lett. 2017 Dec 15; 9(1):51-55.
8 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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