Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0X7PA)
DIG Name
D&C red no. 22
Synonyms    Click to Show/Hide the Synonyms of This DIG
Eosin; Eosin yellowish; Eosin Y; Eosine Yellowish; Eosine; Bromoeosine; Sodium eosine; C.I. Acid Red 87; Bromo acid; Eosine G; Eosine Y; Sodium eosinate; 548-26-5; D and C Red No. 22; Bromofluoresceic acid; Bronze Bromo; Certiqual Eosine; Aizen eosine GH; Bromo Fluorescein; Eosine A; Eosine J; Eosine BS; Eosine DA; Eosine FA; Eosine GF; Eosine OJ; Eosine Salt Free; Eosine w/s; Eosine YB; Eosine YS; Phloxine Toner B; Toyo Eosine G; Bromo B; Eosine BPC; Pure Eosine YY; Bromo FL; Bromo TS; Bromo XX; Eosin YS; Fenazo Eosine XG; Bromo JPS; Eosine 3G; Eosine 3Y; Eosine BS-SF; Bromo 4D; UNII-TDQ283MPCW; Bromo 4DC; Bromo 4DL; Eosine Lake Red Y; Hidacid White Bromo; Symuler Eosin Toner; Eosine K Salt Free; D&C Red No. 22; Eosine DWC 73; Hidacid Boiling Bromo; Eosine S 13; 1903 Yellow Pink; Tetrabromofluorescein D; Tetrabromofluorescein S; 2,4,5,7-Tetrabromo-3,6-fluorandiol; Irgalite Bronze Red CL; Bromo X-100; Hidacid Eosine Soda Salt; Hidacid Bromo acid regular; Hidacid Dibromo Fluorescein; Tetrabromofluorescein soluble; C.I. 45380; Phloxine Red 20-7600; Phlox Red Toner X-1354; TDQ283MPCW; Eosine Extra Conc. A. Export; 11445 Red; 11731 Red; Benzoic acid, 2-(2,4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)-, disodium salt; CI 45380 (Na salt); CHEBI:52053; Eosin Y (C.I. 45380:2); Eosin Y disodium salt (C.I. 45380); Eosin Y, 96%; DSSTox_CID_5234; DSSTox_RID_77710; DSSTox_GSID_25234; Eosin Yellowish (YS); Eosine Yellowish-(YS); Disodium eosin; Eosin gelblich; Morning red; Dawn red; disodium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; Eosine K; Eosin A; Eosine GH; Eosin OJ; Fenazo Eoxine XG; Eosine sodium salt; Cerven kysela 87; 2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9- '-(9H)xanthen)-3-one, disodium salt; D & C Red no. 22; Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,2',4',5',7'-tetrabromo-3',6'-dihydroxy-, disodium salt; Water Red 2; Basacid Red 316; CAS-17372-87-1; Orient Water Red 2; NSC667238; Japan Red 103; Eosine Extra Yellowish; Eosine S13 (bluish); Bromo X 100; Japan Red 230-1; Eosin gelblich [German]; NCGC00166114-02; NCGC00166114-03; NSC 2087; Red No. 103; Cerven kysela 87 [Czech]; Red No. 230-1; CCRIS 6032; 2,4,5,7-Tetrabromofluorescein; Eosin Y powder; Eosin Y Sodium; eosin YS dye; 2-(2,4,5,7-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid, sodium salt, s odium salt; Eosin Y ws; water-soluble eosin; Water soluble eosin; EINECS 241-409-6; C20H6Br4Na2O5; SCHEMBL1506; C20H6Br4O5.2Na; CHEMBL411675; Tetrabromofluorescein Sodium Salt; DTXSID901015574; Tox21_112323; Tox21_302152; SBB057302; AKOS015903636; AKOS016372406; Tox21_112323_1; DB13706; MCULE-3311428648; Acid Red 87 (C.I. 45380); Fluorescein, 2',4',5',7'-tetrabromo-, disodium salt (Benzoic acid tautomeric form); NCGC00255228-01; CI 45380; M372; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, 2Na; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, disodium salt; FT-0625667; ST50997623; T0037; 7549-EP2277565A2; 7549-EP2277566A2; 7549-EP2277567A1; 7549-EP2277568A2; 7549-EP2277569A2; 7549-EP2277570A2; 7549-EP2292280A1; 7549-EP2298753A1; 7549-EP2308510A1; 7549-EP2311464A1; 7549-EP2314574A1; 7549-EP2316974A1; A16376; Q1089206; Fluorescein, 2',4',5',7'-tetrabromo-, disodium salt; 2?4?5?7?Tetrabromofluorescein; UNII-1678RKX8RT component SEACYXSIPDVVMV-UHFFFAOYSA-L; Sodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; 2',4',5',7'-Tetrabromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9-'-(9H)xanthen)-3-one, disodium salt; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-, sodium salt (1:2)
DIG Function
Colorant
PubChem CID
11048
Formula
C20H6Br4Na2O5
Canonical SMILES
C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]
InChI
1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChIKey
SEACYXSIPDVVMV-UHFFFAOYSA-L
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11048"></iframe>
3D MOL is not available 2D MOL
Physicochemical Properties Molecular Weight 691.9 Topological Polar Surface Area 89.5
XlogP N.A. Complexity 797
Heavy Atom Count 31 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 5
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 01 Infectious/parasitic disease Click to Show/Hide
Tetracycline
 API Info
Spotted fever [ICD-11: 1C31]
 [1]
Itraconazole
 API Info
Blastomycosis [ICD-11: 1F22]
 [2]
       ICD Disease Classification 11 Circulatory system disease Click to Show/Hide
Nitroglycerin
 API Info
Acute coronary syndrome [ICD-11: BA4Z]
 [3]
Acebutolol
 API Info
Essential hypertension [ICD-11: BA00]
 [4]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Potential-driven transporter (PDT)
            DBT Name: Organic anion transporter 6 (OAT6) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 4365.16 nM (estimated based on the structural similarity with CHEMBL376503 ) [5]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Mus musculus (Mouse)
                    UniProt ID S22AK_MOUSE
            DBT Name: Organic anion transporter 1 (OAT1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity Ki = 89.13 nM (estimated based on the structural similarity with CHEMBL376503 ) [5]
                    Structural Similarity Tanimoto coefficient = 1
                    Tested Species Mus musculus (Mouse)
                    UniProt ID S22A6_MOUSE
References
1 FDA label for approved tetracycline from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved itraconazole from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved nitroglycerin from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved acebutolol from the official website of the U.S. Food and Drug Administration.
5 Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.

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