Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00476)
Name
Nitroglycerin
Synonyms    Click to Show/Hide the Synonyms of This API
nitroglycerin; Glyceryl trinitrate; Trinitroglycerin; Nitroglycerine; Nitroglycerol; Nitrostat; 55-63-0; Trinitroglycerol; Glycerol trinitrate; Nitro-dur; Minitran; Nitroderm; Nitroglyn; Nitronet; Nitrospan; Tridil; Transderm-nitro; Transderm Nitro; Epinitril; Lenitral; Natispray; Nitrocine; Nitrolan; Nitrolingual; Perlinganit; Susadrin; Sustonit; Trinitrin; Nitrong; Nitro-Bid; Nitroderm TTS; Angiolingual; Cordipatch; Corditrine; Klavikordal; Myoglycerin; Nitroglicerina; Nitroletten; Nitroplast; Nitrorectal; Nitroretard; Nitrostabilin; Nysconitrine; Perglottal; Rectogesic; Temponitrin; Trinitrosan; Adesitrin; Angibid; Angorin; Cardamist; Chitamite; Deponit; Glonoin; Glytrin; Millisrol; Niglycon; Nitrodisc; Nitrogard; Nitroglin; Nitrolowe; Nitromel; Nitromex; Nitromint; Percutol; Suscard; Trinalgon; Triniplas; Trinitrol; Vasoglyn; Myocon; Niglin; Nitora; NitroMist; Gilucor nitro; NitroCor; Blasting oil; Blasting gelatin; Glyceryl nitrate; Nitro-lent; Nitrozell retard; Transiderm-nitro; propane-1,2,3-triyl trinitrate; Coro-Nitro; Nitro-Span; Nitrine-TDC; Spirit of glonoin; Nitrolingual Spray; Glycerin trinitrate; Nitrogliceryna; Nitronal; Transderm-Nitro TTS; Glyceroltrinitraat; Propanetriol Trinitrate; 1,2,3-Propanetriol, trinitrate; 1,2,3-Propanetriyl nitrate; Glycerol, nitric acid triester; Rectiv; Nitroglycerin, spirits of; Spirit of trinitroglycerin; Rcra waste number P081; SK-106N; Solution glyceryl trinitrate; 1,3-dinitrooxypropan-2-yl nitrate; Spirit of glyceryl trinitrate; 1,2,3-propanetrioltrinitrate; NK-843; Glycerol(trinitrate de); 1,2,3-Propanetriol, 1,2,3-trinitrate; UNII-G59M7S0WS3; Glycerol Nitric Acid Triester; 1,2,3-Propanetriol trinitrate; Gilustenon; Trinitrolong; Sustak; NitroBid; G59M7S0WS3; Aldonitrin; Cardiodisco; Colenitral; Discotrine; Glycerylnitrat; Lentonitrina; Nitrobukal; Nitrocerin; Nitrocontin; Nitropatch; Nitropercuten; Nitroperlinit; Nitropront; Nitroprontan; Plastranit; Ratiopharm; Trinipatch; Angiplex; Angonist; Buccard; Cardabid; Cardinit; Dauxona; Diafusor; DTXSID1021407; Glyceryl; Herwicard; Minitram; Mionitrat; Nitradisc; Nitroard; Nitrobaat; Nitroclyn; Nitrocot; Nitrodyl; Nitrolin; Nitropen; Nitroprol; Nitrorex; Nitrovis; Perganit; Polnitrin; Trinitron; Turicard; Vasolator; Vernies; Willong; Anglix; CHEBI:28787; Herzer; Myovin; Nirmin; Nitrek; Sustac; Nitrol Ointment; Trinitrina Erba; Nitradisc Pad; Nitro-Pflaster; Nitrobid Oint; Nitrong Retard; Niong Retard; Nitro Retard; Aquo-Trimitrosan; Nitro Rorer; Nitromack Retard; Nitromint Retard; Nitronal Aqueous; Nitro-Time; Nitrogard-SR; Mi-Trates; Nitradisc TTS; Nitriderm TTS; Nitro-Par; Top-Nitro; Nitrocine 5; Nitrodyl TTS; Nitromint Aerosol; Nitrong-SR; Deponit 5; Deponit-5; Neos nitro OPT; Nit-Ret; Nitroglycerin-ACC; Transderm-N TTS; Nitro Mack Retard; Nitro-M-Bid; Nitro-Mack Retard; Gepan Nitroglicerin; Nitro Dur TTS; Nitroderm TTS-5; GTN-Pohl; Nitroderm TTS Ext; Nitro-Dur 5; Nitrocontin Continus; Deponit TTS 5; Nitro-Gesanit Retard; Cellegesic; Deponit TTS 10; Nitro-Dur 10; Nitrocap; NitroQuick; NitroQuik; NITRO IV; Glycerintrinitrate; Percutol Oint.; Nitrong parenteral; NitrocapT.D.; Glycerine trinitrate; Nitroglycerin (NG); Corangin Nitrokapseln; Trinitroglicerina Fabra; Anogesic; Glonoinum; Gonitro; Minitro; Nitriderm; Nitroject; Vascana; Buccal; Nitrogliceryna [Polish]; Nitroglycerine [French]; Nitrol (pharmaceutical); Tridil sublin; Trinitrine Simple Laleuf; Nitroglicerina [Italian]; Nitroglicerina [Spanish]; Aquo-trinitrosan; Glycerintrinitrate [Czech]; Glyceroltrinitraat [Dutch]; Trinitrin Tablets; NITROLINGUAL PUMPSPRAY; Nitromist (TN); Minitran (TN); HSDB 30; SDM No. 17; Nitroglycerin in Dextrose 5%; Nitro-bid (TN); Nitro-dur (TN); CCRIS 4089; nitroglycerin ointment; Nitric acid triester of gylcerol; Transderm-nitro (TN); Glycerol(trinitrate de) [French]; Glycerol (trinitrate de) [French]; Glycerol (trinitrate de); EINECS 200-240-8; UN0143; UN1204; UN3064; UN3319; Nitroglycerin [USP:JAN]; RCRA waste no. P081; BRN 1802063; 2,3-dinitrooxypropyl nitrate; Nitrofortin; Nitrolande; Nitrosigma; Reminitrol; Solinitrina; Spirits of Nitroglycerin, (1 to 10%); Corangil; Nitrolar; Nitromed; Sutonit; Myocor; trans-nitro; Glonoine oil; Nitro mack; S.N.G.; 2,3-bis(nitrooxy)propyl nitrate; Glycerol-trinitrat; C01DA02; IMX-150; MQX-503; Nitro-PRN; MED-2002; Diluted nitroglycerin; Nitroglycerin tablets; SK-866; SK-878; UN0144; Nitroglycerin Injection; Spirits of nitroglycerin; Nitroglycerine, spirit of; 1,2,3-trinitrooxypropane; CHEMBL730; EC 200-240-8; Nitroglycerin (JP17/USP); 1,2,3-trinitroglycerin-d5; SCHEMBL15421; 4-01-00-02762 (Beilstein Handbook Reference); UN 0143 (Salt/Mix); UN 0144 (Salt/Mix); UN 1204 (Salt/Mix); BIDD:GT0142; Nitroglycerin, liquid, not desensitized [Forbidden]; SDM No. 17 (Salt/Mix); SDM No. 27 (Salt/Mix); 1,2,3-Propanetriol trinatrate; 1,2,3-tris-nitryloxy-propane; GTPL7053; Trinitrate 1,2,3-propanetriol; Nitric acid triester of glycerol; HMS2094M15; ZINC8214625; AKOS030254238; Nitroglycerin, solution in alcohol with > 5% but not > 10% nitroglycerin; DB00727; Nitroglycerin, liquid, not desensitized; FT-0752897; C07455; D00515; 49060-EP2280014A2; 49060-EP2287168A2; 49060-EP2311823A1; 141831-EP2292593A2; Q162867; SR-01000944510; SR-01000944510-1; Nitroglycerin, solution in alcohol, with not >1% nitroglycerin; Nitroglycerin, solution in alcohol, with >1% but not >10% nitroglycerin; Nitroglycerin, solution in alcohol, with >1% but not >5% nitroglycerin; Nitroglycerin mixture with >2% but not >10% nitroglycerin, by mass, desensitized; 27906-99-6
Clinical Status
Approved
Disease Indication Acute coronary syndrome ICD-11: BA4Z [1]
PubChem CID
4510
Formula
C3H5N3O9
Canonical SMILES
C(C(CO[N+](=O)[O-])O[N+](=O)[O-])O[N+](=O)[O-]
InChI
1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2
InChIKey
SNIOPGDIGTZGOP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4510"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 227.09 Topological Polar Surface Area 165
XlogP 1.6 Complexity 219
Heavy Atom Count 15 Rotatable Bond Count 5
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 9
Full List of Drug Formulations (DFMs) Containing This API
          Nitroglycerin 9 mg capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Ferrosoferric oxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Ethylcelluloses; Fd&c green no. 3; Gelatin; Shellac; Starch, corn; White wax
                   Dosage Form Extended Release Oral Capsule
                   Company Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Fd&c yellow no. 6; Sucrose; Talc; Titanium dioxide; Carnauba wax; Ethylcelluloses; Fd&c green no. 3; Gelatin; Shellac; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company Carilion Materials Management; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
          Nitroglycerin 2.5 mg capsule Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Lactose monohydrate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Ferrosoferric oxide; Propylene glycol; Sucrose; Talc; Ethylcelluloses; Gelatin; Shellac; Starch, corn; White wax
                   Dosage Form Extended Release Oral Capsule
                   Company Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Lactose monohydrate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Sucrose; Talc; Ethylcelluloses; Gelatin; Shellac; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acetylated sucrose distearate; Anhydrous lactose; D&c red no. 28; D&c yellow no. 10; Fd&c blue no. 1; Talc; Carnauba wax; Ethylcelluloses; Gelatin; Shellac; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company Carilion Materials Management; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Acetylated sucrose distearate DIG Info Lung cancer NCI-H460 cells (IC50 = 32000 nM) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c yellow no. 10; Fd&c blue no. 1; Sucrose; Talc; Fd&c red no. 3; Gelatin; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
          Nitroglycerin 6.5 mg capsule Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; D&c red no. 33; Fd&c blue no. 1; Fd&c yellow no. 6; Propylene glycol; Sucrose; Talc; Titanium dioxide; Silicon dioxide; Dimethicone; Ethylcelluloses; Gelatin; Shellac; Starch, corn; White wax
                   Dosage Form Extended Release Oral Capsule
                   Company Time Cap Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 22; Lactose monohydrate; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Sucrose; Talc; Ethylcelluloses; Gelatin; Shellac; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 22 DIG Info Organic anion transporter 1 (Ki = 89.13 nM) [6]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c yellow no. 10; D&c red no. 33; Fd&c blue no. 1; Fd&c yellow no. 6; Sucrose; Talc; Gelatin; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; D&c red no. 33; Fd&c blue no. 1; Fd&c yellow no. 6; Sucrose; Talc; Carnauba wax; Ethylcelluloses; Gelatin; Shellac; Starch, corn
                   Dosage Form Extended Release Oral Capsule
                   Company Avera McKennan Hospital; Carilion Materials Management; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
          Nitroglycerin 0.3 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide
                   Dosage Form Sublingual Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company Greenstone; Parke-Davis Div of Pfizer Inc
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Croscarmellose sodium; Silica dimethyl silylate
                   Dosage Form Sublingual Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company Ingenus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nitroglycerin 0.4 mg tablet Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide
                   Dosage Form Sublingual Tablet
                   Company General Injectables & Vaccines; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; Greenstone; Parke-Davis Div of Pfizer Inc; Preferred Pharamaceuticals; Proficient Rx; RemedyRepack; Sina Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide
                   Dosage Form Sublingual Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Polyethylene glycol 3350; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Sublingual Tablet
                   Company Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Magnesium stearate; Polyethylene glycol 3350; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Sublingual Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Croscarmellose sodium; Silica dimethyl silylate
                   Dosage Form Sublingual Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company Ingenus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Silicon dioxide; Hydrogenated cottonseed oil; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company NuCare Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nitroglycerin 0.6 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Glyceryl monostearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company Greenstone; Parke-Davis Div of Pfizer Inc
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [8]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Croscarmellose sodium; Silica dimethyl silylate
                   Dosage Form Sublingual Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Calcium stearate; Silicon dioxide; Starch, corn
                   Dosage Form Sublingual Tablet
                   Company Ingenus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nitroglycerin 300 mcg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Polyethylene glycol 3350; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Sublingual Tablet
                   Company Glenmark Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nitroglycerin 400 mcg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Polyethylene glycol 3350; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Sublingual Tablet
                   Company Glenmark Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Nitroglycerin 600 mcg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Polyethylene glycol 3350; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Sublingual Tablet
                   Company Glenmark Generics
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved nitroglycerin from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.
7 Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity. Medchemcomm. 2014 Aug; 5(8):1138-1142.
8 Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds. J Nat Prod. 2002 Feb; 65(2):206-9.

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