Details of the Drug Formulation (DFM)
General Information of DFM (ID: F06208) | |||||
---|---|---|---|---|---|
Name |
Dimenhydrinate 50 mg tablet
|
||||
Company |
Medtech Products
|
||||
Active Pharmaceutical Ingredient (API) | Dimenhydrinate | API Info click to show the detail info of this API | |||
Functional nausea/vomiting | ICD-11: DD90 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0BI3X | DIG Info | Aspartame | Flavoring agent | ||
E0NN4I | DIG Info | Dextrin | Binding agent ... | ||
E04KSN | DIG Info | Hexahydric alcohol | Diluent ... | ||
E0F6AN | DIG Info | Kyselina citronova | Acidulant ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E0L0MR | DIG Info | Sunset yellow FCF | Colorant | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
---|---|---|---|---|---|---|
Oxidoreductase (ORase) | ||||||
DBT Name: N1-methyl adenine demethylase (FTO) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 300000 nM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | FTO_HUMAN | |||||
DBT Name: RNA demethylase ALKBH5 (ALKB5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 488000 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ALKB5_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Matrix metalloproteinase-1 (MMP1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Aspartame | |||||
Biological Activity | IC50 = 20000 nM (estimated based on the structural similarity with CHEMBL62186 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.916666667 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MMP1_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sunset yellow FCF | |||||
Biological Activity | Inhibition ratio = 54.5 % (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sunset yellow FCF | |||||
Biological Activity | Ki = 68.4 uM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sunset yellow FCF | |||||
Biological Activity | Ki = 74 uM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Factor HNF-4-alpha (HNF4A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 39869 nM (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | HNF4A_HUMAN | |||||
DBT Name: Pregnane X receptor (NR1I2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Aspartame | |||||
Biological Activity | Ki = 13 uM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NR1I2_HUMAN | |||||
Other protein families (OPF) | ||||||
DBT Name: Perilipin-1 (PLIN1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 3708 nM (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PLIN1_HUMAN | |||||
DBT Name: Thrombopoietin receptor (MPL) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sunset yellow FCF | |||||
Biological Activity | EC50 = 3000 nM (estimated based on the structural similarity with CHEMBL122867 ) | [8] | ||||
Structural Similarity | Tanimoto coefficient = 0.93081761 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | TPOR_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Colon cancer Caco-2 cells (Caco-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Dextrin | |||||
Biological Activity | Inhibition ratio > 55 % (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.