Details of the Drug Formulation (DFM)
General Information of DFM (ID: F07660) | |||||
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Name |
Eszopiclone 3 mg tablet
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Company |
Dr Reddy's Laboratories; RemedyRepack
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Active Pharmaceutical Ingredient (API) | Eszopiclone | API Info click to show the detail info of this API | |||
Insomnia | ICD-11: 7A00 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E03SQI | DIG Info | Carmellose sodium | Disintegrant | ||
E0L3MB | DIG Info | FD&C blue no. 2 | Colorant | ||
E00DHW | DIG Info | Lactose monohydrate | Binding agent ... | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E0PC2L | DIG Info | Polyethylene glycol 400 | Coating agent ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
E0T2AJ | DIG Info | Triacetin | Humectant ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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G-protein coupled receptor (GPCR) | ||||||
DBT Name: Adenosine receptor A3 (AA3R) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | IC50 = 1 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | AA3R_HUMAN | |||||
Oxidoreductase (ORase) | ||||||
DBT Name: Monoamine oxidase A (MAO-A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | IC50 > 3 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | AOFA_HUMAN | |||||
DBT Name: Prostaglandin G/H synthase 2 (COX-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | IC50 = 24 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PGH2_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carmellose sodium | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Carmellose sodium | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (4) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | IC50 = 10.77 mg.mL-1 (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Transferase (TFase) | ||||||
DBT Name: VEGF-2 receptor (KDR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | IC50 = 3.1 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | VGFR2_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Protein-tyrosine phosphatase 1D (PTPN11) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | IC50 = 7940 nM (estimated based on the structural similarity with CHEMBL3692077 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.822222222 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PTN11_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 2 (ABCC2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | Inhibition ratio = 67 % (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | Inhibition ratio > 73 % (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MRP2_HUMAN | |||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | Inhibition ratio = 28 % (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | Inhibition ratio = 64 % (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | Inhibition ratio = 26 % (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
DBT Name: Solute carrier SLCO1A2 (OATP-A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | IC50 = 0.14 %(w/v) (tested by experiment) | [10] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1A2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 400 | |||||
Biological Activity | IC50 = 0.05 %(w/v) (tested by experiment) | [10] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO1A2_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Estrogen receptor alpha (ESR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | FD&C blue no. 2 | |||||
Biological Activity | IC50 > 10 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
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