Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00638)
Name	Spironolactone
Synonyms	Click to Show/Hide the Synonyms of This API spironolactone; Aldactone; Spirolactone; Verospiron; Euteberol; Spirolang; Verospirone; Spiroctan; Acelat; Aldactone A; Spironocompren; Melarcon; Spiresis; Spiridon; Uractone; Urusonin; Alderon; Spirone; Xenalon; Spiro-Tablinen; Spironolactone A; spironolattone; Aquareduct; Aldopur; Espironolactona; Spironolactonum; Aldace; Almatol; Deverol; Berlactone; SC 9420; SC-9420; UNII-27O7W4T232; MFCD00082250; CHEMBL1393; C24H32O4S; CHEBI:9241; Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan); Spironolattone [DCIT]; 27O7W4T232; NSC-150399; Spironolactone, 99%; Aldactide; Spiractin; Spironolactonum [INN-Latin]; Espironolactona [INN-Spanish]; DSSTox_CID_14186; DSSTox_RID_79120; DSSTox_GSID_34186; SC 15983; Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]; Diatense; Aldactone (TN); SMR000471892; HSDB 3184; EINECS 200-133-6; NSC 150399; BRN 0057767; spirotone; Spiranolactone; Carospir; CAS-52-01-7; NCGC00015948-02; 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone; Spironolactone [USP:INN:BAN:JAN]; Prestwick0_000128; Prestwick1_000128; Prestwick2_000128; Prestwick3_000128; BIDD:PXR0071; SCHEMBL20939; BSPBio_000176; 4-18-00-01601 (Beilstein Handbook Reference); MLS001074672; MLS001333253; MLS001333254; MLS002153245; MLS002207058; MLS002548846; SPBio_002115; BPBio1_000194; GTPL2875; DTXSID6034186; Spironolactone (JP17/USP/INN); HMS1568I18; HMS2090N21; HMS2095I18; HMS2236E06; HMS3259G11; HMS3712I18; ACT02596; HY-B0561; Spironolactone, 97.0-103.0%; ZINC3861599; Tox21_113047; Tox21_302154; 7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone; BDBM50228080; NSC150399; 4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate; AKOS015896401; AC-4214; CCG-220128; DB00421; KS-5234; MCULE-4394091100; NC00482; NCGC00164397-01; NCGC00164397-02; NCGC00164397-03; NCGC00164397-05; NCGC00255229-01; AK546740; CPD000471892; Spironolactone 1.0 mg/ml in Acetonitrile; AB00513806; 7080-EP2269989A1; 7080-EP2270011A1; 7080-EP2272841A1; 7080-EP2295406A1; 7080-EP2298772A1; 7080-EP2298776A1; 7080-EP2301936A1; 7080-EP2308562A2; 7080-EP2308839A1; C07310; D00443; AB01275520-01; AB01275520_02; 082S250; Q422188; SR-01000765419; SR-05000000452; Q-201737; SR-01000765419-2; SR-05000000452-2; BRD-K90027355-001-03-4; BRD-K90027355-001-19-0; Z1551900341; Spironolactone, European Pharmacopoeia (EP) Reference Standard; WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ; 17.alpha.-Pregn-4-ene-21-carboxylic acid, .gamma.-lactone acetate; Spironolactone, United States Pharmacopeia (USP) Reference Standard; 17.alpha.-Pregn-4-ene-21-carboxylic acid, .gamma.-lactone, acetate; Pregn-4-ene-21-carboxylic acid, .gamma.-lactone, (7.alpha.,17.alpha.)-; (7?,17?)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid ?-lactone
Clinical Status	Approved
Disease Indication	Congestive heart failure		ICD-11: BD10	[1]
PubChem CID	5833
Formula	C24H32O4S
Canonical SMILES	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]3[C@@H]1[C@@H]4CC[C@]5([C@]4(CC3)C)CCC(=O)O5)C
InChI	1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
InChIKey	LXMSZDCAJNLERA-ZHYRCANASA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5833"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	416.6	Topological Polar Surface Area	85.7
	XlogP	2.9	Complexity	818
	Heavy Atom Count	29	Rotatable Bond Count	2
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	5

Full List of Drug Formulations (DFMs) Containing This API
Spironolactone 25 mg tablet			Click to Show/Hide the Full List of Formulation(s): 41 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Povidone; Silicon dioxide; Hypromelloses; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	McKesson
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 2	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Silicon dioxide; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	NCS HealthCare of KY, Inc dba Vangard Labs
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 3	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Silicon dioxide; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Aphena Pharma Solutions-Tennessee; Mylan Pharamceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 4	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 5	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	NuCare Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 6	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Ammonium laureth-5 sulfate; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Polydextrose; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Cardinal Health
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 7	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Mylan Pharamceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 8	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	A-S Medication Solutions; Bryant Ranch Prepack; Unit Dose Services
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 9	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals; Sun Pharmaceutical Industries
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 10	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Stearic acid; Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hypromellose 2910 (15000 mpa.s); Peppermint; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	G.D. Searle LLC Division of Pfizer Inc
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Stearic acid	DIG Info	Phosphodiesterase 3A (IC50 = 3.1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
Drug Formulation 11	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Stearic acid; Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hypromellose 2910 (15000 mpa.s); Peppermint; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Greenstone
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Stearic acid	DIG Info	Phosphodiesterase 3A (IC50 = 3.1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
Drug Formulation 12	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Hypromellose; Povidone; Silicon dioxide; Dextrose; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	State of Florida DOH Central Pharmacy
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Hypromellose	DIG Info	Cytochrome P450 3A5 (IC50 = 19.4 uM)	[3]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 13	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	Rebel Distributors
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 14	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	Physicians Total Care
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 15	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 16	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	AvPAK
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 17	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 18	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone k30; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	Actavis Pharma; Bryant Ranch Prepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 19	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Hypromellose; Polysorbate 80; Povidone; Cellulose, microcrystalline; Polyethylene glycol; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	State of Florida DOH Central Pharmacy
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Hypromellose	DIG Info	Cytochrome P450 3A5 (IC50 = 19.4 uM)	[3]
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 20	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Povidone k29/32; Starch, corn
Dosage Form	Oral Tablet
Company	Carilion Materials Management; Lake Eire Medical & Surgical Supply DBA Quality Care Products
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 21	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Silicon dioxide; Hypromelloses; Peppermint oil; Povidone k25; Starch, corn
Dosage Form	Oral Tablet
Company	Accord Healthcare; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 22	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 23	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	Par Pharmaceutical
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 24	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Dispensing Solution
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 25	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Croscarmellose sodium; Povidone; Cellulose, microcrystalline; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol 8000; Starch, corn
Dosage Form	Oral Tablet
Company	McKesson
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 26	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate, unspecified form; Titanium dioxide; Triacetin; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Dextrose, unspecified form; Hypromelloses; Peppermint oil; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Major Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 27	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate, unspecified form; Titanium dioxide; Triacetin; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Dextrose, unspecified form; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 28	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Povidone; Hypromelloses; Peppermint; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	RedPharm
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 29	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Povidone; Hypromelloses; Peppermint; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	Aidarex Pharmaceuticals; NuCare Pharmaceuticals; RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 30	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	A-S Medication Solutions; Aidarex Pharmaceuticals; American Health Packaging; NCS HealthCare of KY, Inc dba Vangard Labs
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 31	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Croscarmellose sodium; Cellulose, microcrystalline; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol 8000; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 32	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 33	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Croscarmellose sodium; Cellulose, microcrystalline; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol 8000; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Amneal Pharmaceuticals; Blenheim Phamacal; Contract Pharmacal; PD-Rx Pharmaceuticals; State of Florida DOH Central Pharmacy
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 34	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Hypromellose, unspecified; Microcrystalline cellulose; Peppermint; Polydextrose; Polyethylene glycol 8000; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	A-S Medication Solutions
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 35	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Cellulose, microcrystalline; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol 8000; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Amneal Pharmaceuticals; RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 36	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate, unspecified form; Talc; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	Lake Eire Medical & Surgical Supply DBA Quality Care Products; PD-Rx Pharmaceuticals; Proficient Rx
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 37	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate, unspecified form; Titanium dioxide; Triacetin; Croscarmellose sodium; Hypromellose, unspecified; Microcrystalline cellulose; Peppermint; Polydextrose; Polyethylene glycol 8000; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Cardinal Health
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 38	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate, unspecified form; Titanium dioxide; Triacetin; Croscarmellose sodium; Cellulose, microcrystalline; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol 8000; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 39	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Titanium dioxide; Polysorbate 80; Hypromelloses; Peppermint; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Sandoz
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 40	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Crospovidone, unspecified; Hypromellose, unspecified; Peppermint; Polyethylene glycol, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Proficient Rx
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 41	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Hypromelloses; Peppermint; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Spironolactone 50 mg tablet			Click to Show/Hide the Full List of Formulation(s): 25 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Titanium dioxide; Triacetin; Hypromellose; Povidone; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Polydextrose; Polyethylene glycol; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	McKesson
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Hypromellose	DIG Info	Cytochrome P450 3A5 (IC50 = 19.4 uM)	[3]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 2	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Croscarmellose sodium; Polyvinyl alcohol; Povidone; Cellulose, microcrystalline; Peppermint; Polyethylene glycol 3000; Starch, corn
Dosage Form	Oral Tablet
Company	McKesson
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sunset yellow FCF	DIG Info	Solute carrier SLCO2B1 (Ki = 68.4 uM)	[2]
	Quinoline yellow WS	DIG Info	Estrogen receptor alpha (IC50 = 18 uM)	[6]
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[3]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 3	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Silicon dioxide; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	NCS HealthCare of KY, Inc dba Vangard Labs
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 4	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Silicon dioxide; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Mylan Pharamceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 5	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Croscarmellose sodium; Polyvinyl alcohol; Cellulose, microcrystalline; Peppermint; Polyethylene glycol 3000; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Amneal Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sunset yellow FCF	DIG Info	Solute carrier SLCO2B1 (Ki = 68.4 uM)	[2]
	Quinoline yellow WS	DIG Info	Estrogen receptor alpha (IC50 = 18 uM)	[6]
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 6	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Calcium sulfate dihydrate; Talc; Titanium dioxide; Croscarmellose sodium; Polyvinyl alcohol; Cellulose, microcrystalline; Peppermint; Polyethylene glycol 3000; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Amneal Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sunset yellow FCF	DIG Info	Solute carrier SLCO2B1 (Ki = 68.4 uM)	[2]
	Quinoline yellow WS	DIG Info	Estrogen receptor alpha (IC50 = 18 uM)	[6]
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 7	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Ammonium laureth-5 sulfate; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Polydextrose; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Cardinal Health
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 8	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Mylan Pharamceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 9	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	NuCare Pharmaceuticals; Preferred Pharamaceuticals; Unit Dose Services
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 10	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Carnauba wax; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Polydextrose; Polyethylene glycol, unspecified; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Bryant Ranch Prepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 11	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromelloses; Polydextrose; Polyethylene glycols; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Sun Pharmaceutical Industries
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 12	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Stearic acid; Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hypromellose 2910 (15000 mpa.s); Peppermint; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	G.D. Searle LLC Division of Pfizer Inc
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Stearic acid	DIG Info	Phosphodiesterase 3A (IC50 = 3.1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
Drug Formulation 13	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Stearic acid; Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hypromellose 2910 (15000 mpa.s); Peppermint; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Greenstone
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Stearic acid	DIG Info	Phosphodiesterase 3A (IC50 = 3.1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
Drug Formulation 14	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Hypromellose; Povidone; Silicon dioxide; Dextrose; Peppermint oil; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	Major Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Hypromellose	DIG Info	Cytochrome P450 3A5 (IC50 = 19.4 uM)	[3]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 15	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	Lake Eire Medical & Surgical Supply DBA Quality Care Products
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 16	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	Physicians Total Care
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 17	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone k30; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	Actavis Pharma
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 18	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Silicon dioxide; Hypromellose, unspecified; Peppermint oil; Povidone k25; Starch, corn
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 19	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Silicon dioxide; Hypromelloses; Peppermint oil; Povidone k25; Starch, corn
Dosage Form	Oral Tablet
Company	Accord Healthcare
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 20	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Rebel Distributors
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 21	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	Par Pharmaceutical
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 22	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Povidone; Hypromelloses; Peppermint; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	NuCare Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 23	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	Aidarex Pharmaceuticals; American Health Packaging
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 24	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Titanium dioxide; Povidone; Hypromelloses; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	PD-Rx Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 25	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate, unspecified form; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Hypromellose, unspecified; Peppermint; Polyethylene glycol, unspecified; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Proficient Rx
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Spironolactone 100 mg tablet			Click to Show/Hide the Full List of Formulation(s): 22 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Silicon dioxide; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	NCS HealthCare of KY, Inc dba Vangard Labs
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 2	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Crospovidone; Silicon dioxide; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Mylan Pharamceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 3	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Ammonium laureth-5 sulfate; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Polydextrose; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Cardinal Health
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 4	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Calcium sulfate dihydrate; Titanium dioxide; Triacetin; Croscarmellose sodium; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Polydextrose; Polyethylene glycol, unspecified; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Mylan Pharamceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium lauryl sulfate	DIG Info	Solute carrier SLCO2B1 (Ki = 1.98 uM)	[2]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 5	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%); Hypromelloses; Polydextrose; Polyethylene glycols; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	RemedyRepack; Sun Pharmaceutical Industries
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 6	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Anhydrous lactose; Sodium benzoate; Docusate sodium; Magnesium stearate; Titanium dioxide; Triacetin; Silicon dioxide; Carnauba wax; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Polydextrose; Polyethylene glycol, unspecified; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Bryant Ranch Prepack; Unit Dose Services
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Sodium benzoate	DIG Info	Carbonic anhydrase II (Ki = 30000 nM)	[5]
	Docusate sodium	DIG Info	Solute carrier SLCO2B1 (Ki = 2.3 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 7	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Stearic acid; Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hypromellose 2910 (15000 mpa.s); Peppermint; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	G.D. Searle LLC Division of Pfizer Inc
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Stearic acid	DIG Info	Phosphodiesterase 3A (IC50 = 3.1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
Drug Formulation 8	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Stearic acid; Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Titanium dioxide; Polyethylene glycol 400; Carnauba wax; Hypromellose 2910 (15000 mpa.s); Peppermint; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	Greenstone
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Stearic acid	DIG Info	Phosphodiesterase 3A (IC50 = 3.1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
Drug Formulation 9	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Hypromellose; Povidone; Silicon dioxide; Dextrose; Peppermint oil; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	Major Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Hypromellose	DIG Info	Cytochrome P450 3A5 (IC50 = 19.4 uM)	[3]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 10	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycol; Starch, corn
Dosage Form	Oral Tablet
Company	Physicians Total Care
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 11	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Polyvinyl alcohol; Cellulose, microcrystalline; Peppermint; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Amneal Pharmaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Polyethylene glycol 3350	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 12	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Polyvinyl alcohol; Cellulose, microcrystalline; Peppermint; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Amneal Pharmaceuticals; RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polyvinyl alcohol	DIG Info	Debrisoquine 4-hydroxylase (EC50 = 354.8 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Polyethylene glycol 3350	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 13	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Maltodextrin; Magnesium stearate; Calcium sulfate; Titanium dioxide; Triacetin; Crospovidone; Povidone k30; Silicon dioxide; Dextrose; Hypromelloses; Peppermint; Polydextrose; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	Actavis Pharma
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Dextrin	DIG Info	Colon cancer Caco-2 cells (Inhibition ratio > 55 %)	[8]
	Crospovidone	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 14	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Hypromellose; Polysorbate 80; Povidone; Cellulose, microcrystalline; Polyethylene glycol; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	State of Florida DOH Central Pharmacy
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Hypromellose	DIG Info	Cytochrome P450 3A5 (IC50 = 19.4 uM)	[3]
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 15	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate dihydrate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Microcrystalline cellulose; Peppermint; Polyvinyl alcohol, unspecified; Povidone, unspecified; Starch, corn
Dosage Form	Oral Tablet
Company	A-S Medication Solutions
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Carmellose sodium	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
	Polyethylene glycol 3350	DIG Info	Albendazole monooxygenase (Protein expression upregulation)	[4]
Drug Formulation 16	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Silicon dioxide; Hypromellose, unspecified; Peppermint oil; Povidone k25; Starch, corn
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 17	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Dibasic calcium phosphate dihydrate; Ferric oxide red; Ferric oxide yellow; Talc; Titanium dioxide; Polyethylene glycol 400; Silicon dioxide; Hypromelloses; Peppermint oil; Povidone k25; Starch, corn
Dosage Form	Oral Tablet
Company	Accord Healthcare
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
	Polyethylene glycol 400	DIG Info	Albendazole monooxygenase (IC50 = 10.77 mg.mL-1)	[7]
	Silicon dioxide	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 18	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Sodium starch glycolate type a potato
Dosage Form	Oral Tablet
Company	Lake Eire Medical & Surgical Supply DBA Quality Care Products
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 19	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Povidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	PD-Rx Pharmaceuticals; Par Pharmaceutical
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 20	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Povidone; Hypromelloses; Peppermint; Polyethylene glycols; Starch, corn
Dosage Form	Oral Tablet
Company	RemedyRepack
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Povidone	DIG Info	Cholesterol 25-hydroxylase (IC50 = 78.3 uM)	[3]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 21	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate; Talc; Titanium dioxide; Polysorbate 80; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones; Sodium starch glycolate type a potato; Starch, corn
Dosage Form	Oral Tablet
Company	Aidarex Pharmaceuticals; American Health Packaging
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Polysorbate 80	DIG Info	Prostaglandin G/H synthase 1 (IC50 = 1 uM)	[6]
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]
Drug Formulation 22	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Magnesium stearate; Calcium sulfate, unspecified form; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Titanium dioxide; Hypromelloses; Peppermint; Polyethylene glycols; Povidones; Starch, corn
Dosage Form	Oral Tablet
Company	Preferred Pharamaceuticals
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Magnesium stearate	DIG Info	Albendazole monooxygenase (Protein expression downregulation)	[4]

References
1	FDA label for approved spironolactone from the official website of the U.S. Food and Drug Administration.
2	Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
6	The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
7	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
8	Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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