Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00185)
Name
Dexamethasone
Synonyms    Click to Show/Hide the Synonyms of This API
dexamethasone; Decadron; Maxidex; Dexamethazone; Dexasone; Hexadrol; Oradexon; Prednisolone F; Cortisumman; Decaspray; Desametasone; Hexadecadrol; Millicorten; Auxiron; Calonat; Dexacort; Dexason; Fluormethylprednisolone; Aeroseb-Dex; Deltafluorene; Desamethasone; Mediamethasone; Superprednol; Visumetazone; Aphtasolon; Decaderm; Decasone; Dectancyl; Dekacort; Dergramin; Desadrene; Desameton; Dexacortal; Dexacortin; Dexadeltone; Dexalona; Dexameth; Dexapolcort; Dextelan; Dinormon; Fortecortin; Gammacorten; Mymethasone; Turbinaire; Corsone; Decalix; Dexone; Mexidex; Dexa-Cortidelt; Dexa-Cortisyl; Dexa-Scheroson; Prednisolon F; Aeroseb-D; SK-Dexamethasone; Anaflogistico; Decacortin; Deseronil; Dexafarma; Dexaprol; Dexinolon; Dexinoral; Loverine; Luxazone; Policort; Spoloven; Decagel; Deronil; Dezone; Sunia Sol D; Bisu DS; Dexa Mamallet; Hexadrol Elixir; Dexa-sine; Lokalison F; Isopto-Dex; Ocu-trol; Dex-ide; Hl-dex; Dexamethasonum; Dexone 4; Fluorocort; Decaject; Decameth; Fluormone; Corson; Dexpak; Pet Derm III; Dexamethasone alcohol; Hexadrol Tablets; Dexamethasone Intensol; Methylfluorprednisolone; Desametasone [DCIT]; Dexone 0.5; Dexone 1.5; Dexone 0.75; Dexametasona; Dexacidin; Maxitrol; Dexametasona [INN-Spanish]; Dexamethasonum [INN-Latin]; Decadron Tablets, Elixir; Azium (Veterinary); Dexamethansone; Ozurdex; Posurdex; Prodex; MK 125; C22H29FO5; OTO-104; (3H)-Dexamethasone; Azimycin (Veterinary); NSC 34521; Naquasone (Veterinary); Tresaderm (Veterinary); 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol; 16alpha-Methyl-9alpha-fluoroprednisolone; 16-alpha-Methyl-9-alpha-fluoroprednisolone; 9-alpha-Fluoro-16-alpha-methylprednisolone; UNII-7S5I7G3JQL; 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone; 9alpha-Fluoro-16alpha-methylprednisolone; delta1-9alpha-Fluoro-16alpha-methylcortisol; MFCD00064136; Decacort; Dexamethasone (DHAP); 16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol; 16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone; delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol; 9A-FLUORO-16BETA-METHYLPREDNISOLONE; 16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone; 16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone; 7S5I7G3JQL; CHEBI:41879; ISV-305; [3H]-dexamethasone; NSC-34521; Decaject-L.A.; Dexamethasone, 96%; Dexair; 16.alpha.-Methyl-9.alpha.-fluoroprednisolone; 9.alpha.-Fluoro-16.alpha.-methylprednisolone; Dexacen-4; 16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol; 1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone; Dextenza; Osurdex; Dexamethasone Base; Decadron (TN); SMR000857119; DXM [Steroid]; CCRIS 7067; HSDB 3053; dexamethasone (tetramethyl-rhodamine conjugated ); Prednisolone, 9.alpha.-fluoro-16.alpha.-methyl-; EINECS 200-003-9; Dexametasone; Solurex; .delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol; 16.alpha.-Methyl-9.alpha.-fluoro-.delta.(sup1)-hydrocortisone; Diodex; DexaSite; NSC34521; AI3-50934; .gamma.corten; Apo-dexamethasone; Prednisolone, 9alpha-fluoro-16alpha-methyl-; Dexasone 4mg; Zema-Pak; PHL-dexamethasone; PMS-dexamethasone; [3H]dexamethasone; Dexamethasone-omega; NCGC00091019-08; Dexasone 0.5mg; Dexamethasone [USP:INN:BAN:JAN]; Dexasone 0.75mg; Sandoz Dexamethasone; Dexamethasone, topical; Maxidex Ont 0.1%; Maxidex Sus 0.1%; dexamethasone-17-acetate; DSSTox_CID_384; Spectrum5_002019; MolMap_000018; 9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione; SCHEMBL3774; DSSTox_RID_75557; BIDD:PXR0060; DSSTox_GSID_20384; BSPBio_000995; MLS001055412; MLS001332507; MLS001332508; ARONIS27003; BIDD:ER0494; sustained-release dexamethasone; CHEMBL384467; GTPL2768; GTPL3447; SGCUT00126; 9-Fluoro-16-methylprednisolone; Ak Dex Oph Otic Soln 0.1%; DTXSID3020384; BDBM18207; Dexamethasone (JP17/USP/INN); HMS1792A17; HMS1990A17; HMS2089N13; HMS2235F08; HMS3039L11; HMS3259N11; HMS3403A17; Dexamethasone Cyclodextrin complex; to_000038; ZINC3875332; Tox21_200122; Dexamethasone, >=97.0% (HPLC); IBI-10090; Dexamethasone 1.0 mg/ml in Methanol; PMS Dexamethasone Elixir 0.5mg/5ml; AKOS005259009; AKOS015895509; Decadron phosphate, Decdan, Dexacort,; ACN-036253; CCG-264887; CS-1505; DB01234; KS-1451; MCULE-4773827191; NC00645; alpha -Fluoro-16-alpha -methylcortisol; CAS-50-02-2; Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-; SMP1_000092; Dexamethasone, >=98% (HPLC), powder; NCGC00091019-01; NCGC00091019-02; NCGC00091019-03; NCGC00091019-04; NCGC00091019-05; NCGC00091019-06; NCGC00091019-07; NCGC00091019-23; NCGC00257676-01; 23495-06-9; 9alpha-fluoro-16alpha-methyl-Prednisolone; AC-11056; HY-14648; NCI60_003067; SMR001227192; 16alpha -Methyl-9alpha -fluoroprednisolone; 9alpha -Fluoro-16alpha -methylprednisolone; AB0072035; Dexamethasone, tested according to Ph.Eur.; ST50307091; EN300-52607; 1793-EP2269977A2; 1793-EP2269989A1; 1793-EP2269990A1; 1793-EP2270008A1; 1793-EP2270014A1; 1793-EP2270018A1; 1793-EP2272832A1; 1793-EP2275420A1; 1793-EP2277565A2; 1793-EP2277566A2; 1793-EP2277567A1; 1793-EP2277568A2; 1793-EP2277569A2; 1793-EP2277570A2; 1793-EP2277861A1; 1793-EP2277865A1; 1793-EP2277876A1; 1793-EP2279741A2; 1793-EP2281563A1; 1793-EP2289894A2; 1793-EP2292227A2; 1793-EP2292280A1; 1793-EP2292589A1; 1793-EP2292614A1; 1793-EP2292617A1; 1793-EP2295055A2; 1793-EP2295402A2; 1793-EP2295409A1; 1793-EP2295412A1; 1793-EP2295413A1; 1793-EP2295416A2; 1793-EP2298731A1; 1793-EP2298743A1; 1793-EP2298748A2; 1793-EP2298764A1; 1793-EP2298765A1; 1793-EP2298772A1; 1793-EP2298778A1; 1793-EP2298779A1; 1793-EP2298780A1; 1793-EP2305248A1; 1793-EP2305642A2; 1793-EP2305663A1; 1793-EP2305689A1; 1793-EP2308562A2; 1793-EP2308812A2; 1793-EP2308833A2; 1793-EP2308839A1; 1793-EP2308880A1; 1793-EP2311453A1; 1793-EP2314585A1; 1793-EP2314590A1; 1793-EP2316459A1; 1793-EP2316832A1; 1793-EP2316833A1; 1793-EP2316834A1; 1793-EP2371811A2; C15643; D00292; Dexamethasone, meets USP testing specifications; J10029; Prednisolone, 9alpha -fluoro-16alpha -methyl-; W-5058; 9.alpha.-Fluoro-16.alpha.-methyl-1,20-dione; AB00918428-05; AB00918428-08; AB00918428-09; AB00918428_10; 064D136; 16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol; Dexamethasone, VETRANAL(TM), analytical standard; Q422252; Neomycin and polymyxin b sulphates and dexamethasone; Q-200939; BRD-K38775274-001-02-3; BRD-K38775274-001-06-4; 1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone; 9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione; Dexamethasone, British Pharmacopoeia (BP) Assay Standard; Z802671480; Pregna-1,4-diene-3,20-dione, 9-fluoro-11alpha -methyl-; Dexamethasone, European Pharmacopoeia (EP) Reference Standard; WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1; Dexamethasone, powder, BioReagent, suitable for cell culture, >=97%; Dexamethasone, United States Pharmacopeia (USP) Reference Standard; 16-.alpha.-Methyl-9-.alpha.-fluoro-1,17-.alpha.,21-triol-3,20-dione; 4.alpha.-Fluoro-16.alpha.-methyl-11.beta.-17,4-diene-3,20-dione; 9a-Fluoro-11b,17a,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione; Pregna-1,20-dione, 9-fluoro-11.beta.,17,21-trihydroxy-16.alpha.-methyl-; 9-Fluoro-11.beta.,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione; 9-fluoro-16alpha-methyl-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione; Dexamethasone, Pharmaceutical Secondary Standard; Certified Reference Material; 1050677-47-8
Clinical Status
Approved
Disease Indication Rheumatoid arthritis ICD-11: FA20 [1]
PubChem CID
5743
Formula
C22H29FO5
Canonical SMILES
C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
InChI
1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey
UREBDLICKHMUKA-CXSFZGCWSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5743"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 392.5 Topological Polar Surface Area 94.8
XlogP 1.9 Complexity 805
Heavy Atom Count 28 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Dexamethasone 6 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Fd&c yellow no. 6; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Fd&c green no. 3; Starch, corn
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Physicians Total Care; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Dexamethasone 0.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Fd&c yellow no. 5; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Physicians Total Care; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Dexamethasone 0.75 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; H. J. Harkins Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; D&c yellow no. 10; Fd&c blue no. 1; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical; Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 1; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; Bryant Ranch Prepack; PD-Rx Pharmaceuticals; Physicians Total Care; Rebel Distributors; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Dexamethasone 1.5 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Sucrose; Fd&c red no. 3; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Blenheim Phamacal
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Xspire Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Fd&c red no. 40; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Par Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [3]
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Maltodextrin; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Larken Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company ECR Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
          Dexamethasone 4 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Sucrose; Fd&c green no. 3; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Bryant Ranch Prepack; Dispensing Solution; Lake Eire Medical & Surgical Supply DBA Quality Care Products; PD-Rx Pharmaceuticals; Physicians Total Care; Proficient Rx; Rebel Distributors; Stat Rx USA; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Sucrose; Fd&c green no. 3; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; Blenheim Phamacal; H. J. Harkins Company; NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company NuCare Pharmaceuticals; Par Pharmaceutical; Preferred Pharamaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Anhydrous lactose; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company RedPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [4]
          Dexamethasone 1 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Rebel Distributors; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Dexamethasone 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; PD-Rx Pharmaceuticals; Physicians Total Care; Proficient Rx; Rebel Distributors; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved dexamethasone from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
5 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

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