Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00300)
Name
Gemfibrozil
Synonyms    Click to Show/Hide the Synonyms of This API
gemfibrozil; 25812-30-0; 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid; CI-719; Clearol; Gemfibrozilo; Gemfibrozilum; Gen-Fibro; 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid; Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-; Decrelip; 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure; Gemfibrozil (Lopid); Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-; Bolutol; Apo-Gemfibrozil; UNII-Q8X02027X3; Cholespid; Gemfibril; Gemfibromax; Hipolixan; Fibratol; Fibrocit; Gemlipid; Lipazil; Litarek; MFCD00079335; Trialmin; Ausgem; Pilder; CHEMBL457; MLS000028421; CHEBI:5296; Renabrazin; Elmogan; Fetinor; Gemnpid; Innogen; Ipolipid; Lanaterom; Lifibron; Lipigem; Lipizyl; Micolip; Normolip; Polyxit; Progemzal; Reducel; Regulip; Sinelip; Synbrozil; Taborcil; Tentroc; Brozil; Lipira; WL-Gemfibrozil; Gevilon Uno; Gemfibrozil, 98%; Low-Lip; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid; 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid; Q8X02027X3; 5-[(2,5-dimethylphenyl)oxy]-2,2-dimethylpentanoic acid; NCGC00016794-09; Lipozid; SMR000058393; CAS-25812-30-0; DSSTox_CID_652; DSSTox_RID_75712; DSSTox_GSID_20652; Gemfibrozilum [INN-Latin]; Gemfibrozilo [INN-Spanish]; Innogem; Gemcor; CI 719; CCRIS 318; Lopid (TN); TEVA-A; SR-01000000056; EINECS 247-280-2; BRN 1881200; Gemfibrozil (JAN/USP/INN); HSDB 7735; Gemfibrozil,(S); Gemfibrozil [USAN:USP:INN:BAN]; Prestwick_637; dimethylpentanoic acid; 5-(2,5-Dimethyl-Phenoxy)-2,2-Dimethyl-Pentanoic Acid; Spectrum_000825; CPD000058393; Opera_ID_1658; Prestwick0_000214; Prestwick1_000214; Prestwick2_000214; Prestwick3_000214; Spectrum2_001097; Spectrum3_000440; Spectrum4_000562; Spectrum5_000750; Spectrum5_001991; SCHEMBL4813; BSPBio_000227; BSPBio_002060; KBioGR_000964; KBioSS_001305; MLS001055364; MLS006011850; ARONIS24091; DivK1c_000138; SPECTRUM1500313; SPBio_001174; SPBio_002148; BPBio1_000251; GTPL3439; Gemfibrozil, analytical standard; DTXSID0020652; HMS500G20; KBio1_000138; KBio2_001305; KBio2_003873; KBio2_006441; KBio3_001280; NINDS_000138; HMS1568L09; HMS1920B07; HMS2090K14; HMS2091H11; HMS2095L09; HMS2230H24; HMS3259M12; HMS3655C06; HMS3712L09; Pharmakon1600-10500313; 5-(2,5-dimethylphenoxy)-2,2-; BCP08437; HY-B0258; ZINC1530641; Tox21_110613; Tox21_201997; Tox21_302784; A0G461; BBL010807; BDBM50110590; CCG-40111; CG0035; DL-414; NSC757024; SBB012457; STK618740; AKOS001606691; Tox21_110613_1; AB03034; AC-4225; DB01241; KS-5192; MCULE-4563546953; NC00565; NSC-757024; VA11004; IDI1_000138; NCGC00016794-01; NCGC00016794-02; NCGC00016794-03; NCGC00016794-04; NCGC00016794-05; NCGC00016794-06; NCGC00016794-07; NCGC00016794-08; NCGC00016794-10; NCGC00016794-11; NCGC00016794-13; NCGC00016794-14; NCGC00022722-03; NCGC00022722-04; NCGC00022722-05; NCGC00022722-06; NCGC00022722-07; NCGC00256601-01; NCGC00259546-01; AK309283; ST072198; SY052512; SBI-0051391.P003; AB0013344; 2,2-Dimethyl-5-(2,5-zlyloxy)valeric acid; AB00052003; FT-0626641; FT-0700924; SW196802-3; C07020; D00334; J10068; Z-0832; AB00052003-15; AB00052003-16; AB00052003_17; AB00052003_18; A818037; Q384295; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeric Acid; SR-01000000056-3; SR-01000000056-4; SR-01000000056-6; SR-01000000056-7; W-107216; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)-pentanoic acid; BRD-K11129031-001-05-1; Gemfibrozil, British Pharmacopoeia (BP) Reference Standard; Gemfibrozil, European Pharmacopoeia (EP) Reference Standard; Gemfibrozil, United States Pharmacopeia (USP) Reference Standard; Gemfibrozil, Pharmaceutical Secondary Standard; Certified Reference Material; 114413-98-8
Clinical Status
Approved
Disease Indication Hypertriglyceridaemia ICD-11: 5C80 [1]
PubChem CID
3463
Formula
C15H22O3
Canonical SMILES
CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O
InChI
1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
InChIKey
HEMJJKBWTPKOJG-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3463"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 250.33 Topological Polar Surface Area 46.5
XlogP 3.8 Complexity 273
Heavy Atom Count 18 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Gemfibrozil 600 mg tablet Click to Show/Hide the Full List of Formulation(s):        36 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Calcium stearate; Fd&c blue no. 1; Isopropyl alcohol; Propylene glycol; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (6 mpa.s); Microcrystalline cellulose; Shellac; Starch, corn
                   Dosage Form Oral Tablet
                   Company Nivagen Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Calcium stearate; Fd&c blue no. 1; Isopropyl alcohol; Propylene glycol; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (6 mpa.s); Shellac; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cadila Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Calcium stearate; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Polyvinyl alcohol; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Starch, corn
                   Dosage Form Oral Tablet
                   Company PuraCap Laboratories; St Marys Medical Park Pharmacy; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Calcium stearate; Talc; Titanium dioxide; Croscarmellose sodium; Polyethylene glycol 3350; Polyvinyl alcohol; Carnauba wax; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Calcium stearate; Propylparaben; Polysorbate 80; Silicon dioxide; Candelilla wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified
                   Dosage Form Oral Tablet
                   Company Parke-Davis Div of Pfizer Inc; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [8]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [5]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Crospovidone; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycol 8000; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Caraco Pharmaceutical Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Triacetin; Water; Hypromellose; Polysorbate 80; Povidone; Silicon dioxide; Cellulose, microcrystalline; Polydextrose; Polyethylene glycol; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Global Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Methylcellulose (15 cps)
                   Dosage Form Oral Tablet
                   Company DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Methylcellulose (15 cps)
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Methylcellulose (15 cps)
                   Dosage Form Oral Tablet
                   Company DirectRX
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Methylcellulose (15 mpa.s)
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Blu Pharmaceuticals; Carilion Materials Management; Clinical Solutions Wholesale; Epic Pharma; NuCare Pharmaceuticals; Preferred Pharamaceuticals; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Methylcellulose (15 mpa.s); Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; American Health Packaging; Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Methylcellulose (15 cps)
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; Camber Pharmaceuticals; Cipla; Contract Pharmacal; Exelan Pharmaceuticals; Kaiser Foundation Hospitals; Lake Eire Medical & Surgical Supply DBA Quality Care Products; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals; RemedyRepack; St Marys Medical Park Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Talc; Titanium dioxide; Magnesium sulfate, unspecified; Polysorbate 80; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Polyethylene glycol; Polyethylene glycol 3000; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Hikma Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Talc; Titanium dioxide; Magnesium sulfate, unspecified; Polysorbate 80; Polyvinyl alcohol; Silicon dioxide; Cellulose, microcrystalline; Polyethylene glycol; Polyethylene glycol 3000; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Titanium dioxide; Polysorbate 80; Polyvinyl alcohol; Cellulose, microcrystalline; Colloidal silicon dioxide; Polyethylene glycol; Polyethylene glycol 3000; Sodium starch glycolate type a potato; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyvinyl alcohol DIG Info Debrisoquine 4-hydroxylase (EC50 = 354.8 uM) [7]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Croscarmellose sodium; Hypromellose; Silicon dioxide; Cellulose, microcrystalline; Methylcellulose (100 cps); Polyethylene glycol
                   Dosage Form Oral Tablet
                   Company Kaiser Foundation Hospitals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (15000 mpa.s); Methylcellulose (1500 mpa.s); Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Med-Health Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromellose 2910 (15000 mpa.s); Methylcellulose (1500 mpa.s); Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Dispensing Solution; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Hypromellose; Polyethylene glycol 4000; Polysorbate 80; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal; Physicians Total Care; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [4]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 400; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hydroxypropyl cellulose, low substituted; Hypromellose 2910 (6 mpa.s); Starch, corn
                   Dosage Form Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 4000; Polysorbate 80; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (15 mpa.s); Microcrystalline cellulose; Polydextrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 4000; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (15 mpa.s); Polydextrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 4000; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2910 (15 mpa.s); Polydextrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company McKesson; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 4000; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polydextrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [4]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 27 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hydroxypropyl cellulose, low substituted; Hypromelloses; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company NorthStar Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 28 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose; Hypromelloses; Methylcellulose (15 cps); Polyethylene glycol
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 29 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methylcellulose (15 mpa.s); Polyethylene glycol, unspecified
                   Dosage Form Oral Tablet
                   Company Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 30 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose (type h); Hypromelloses; Methylcellulose (15 mpa.s); Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Aidarex Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 31 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose; Hypromelloses; Methylcellulose (15 cps); Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 32 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hydroxypropyl cellulose (type h); Hypromelloses; Methylcellulose (15 cps); Polyethylene glycols
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 33 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Titanium dioxide; Polyethylene glycol 4000; Polysorbate 80; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company Contract Pharmacal; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Polyethylene glycol 4000 DIG Info Albendazole monooxygenase (Inhibition ratio < 40 %) [4]
             Drug Formulation 34 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 35 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Blenheim Phamacal; DAVA Pharmaceuticals; PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [6]
             Drug Formulation 36 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Colloidal silicon dioxide; Methylcellulose (100 cps)
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [6]
References
1 FDA label for approved gemfibrozil from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
6 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
7 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
8 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.

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