General Information of DFM (ID: F00642)
Name	Alendronic acid 70 mg tablet
Company	Mission Pharmacal Company
Active Pharmaceutical Ingredient (API)	Alendronic acid		API Info click to show the detail info of this API
	Osteoporosis		ICD-11: FB83	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0TU6R	DIG Info	Acesulfame	Flavoring agent
	E0DB2E	DIG Info	Carbonic acid disodium salt	Alkalizing agent ...
	E0F6AN	DIG Info	Kyselina citronova	Acidulant ...
	E0V3GR	DIG Info	Monosodium citrate	Acidulant ...
	E0G1YW	DIG Info	Sodium bicarbonate	Alkalizing agent ...
	E04KTP	DIG Info	Sucralose	Flavoring agent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: N1-methyl adenine demethylase (FTO)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Kyselina citronova
Biological Activity	IC50 = 300000 nM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	FTO_HUMAN
DBT Name: RNA demethylase ALKBH5 (ALKB5)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Kyselina citronova
Biological Activity	IC50 = 488000 nM (tested by experiment)					[2]
Tested Species	Homo sapiens (Human)
UniProt ID	ALKB5_HUMAN
Lyase/isomerase/ligase (L/I/G)
DBT Name: Carbonic anhydrase II (CA2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acesulfame
Biological Activity	Ki > 20000 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH2_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sucralose
Biological Activity	Ki = 300 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH2_HUMAN
DBT Name: Carbonic anhydrase IX (CA9)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Acesulfame
Biological Activity	Ki = 2400 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH9_HUMAN
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sucralose
Biological Activity	Ki = 2200 nM (tested by experiment)					[3]
Tested Species	Homo sapiens (Human)
UniProt ID	CAH9_HUMAN
Nuclear receptor (NR)
DBT Name: Factor HNF-4-alpha (HNF4A)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Kyselina citronova
Biological Activity	IC50 = 39869 nM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	HNF4A_HUMAN
Other protein families (OPF)
DBT Name: Perilipin-1 (PLIN1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Kyselina citronova
Biological Activity	IC50 = 3708 nM (tested by experiment)					[4]
Tested Species	Homo sapiens (Human)
UniProt ID	PLIN1_HUMAN

References
1	Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J Med Chem. 2013 May 9; 56(9):3680-8.
2	Repair of methyl lesions in RNA by oxidative demethylation. Med Chem Comm. (2014) 5:1797-1803.
3	Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.
4	PubChem BioAssay data set.

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