Details of the Drug Formulation (DFM)
General Information of DFM (ID: F23353) | |||||
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Name |
Penbutolol Sulfate 10mg tablet
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Company |
Auxilium Pharms
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Active Pharmaceutical Ingredient (API) | Penbutolol | API Info click to show the detail info of this API | |||
Essential hypertension | ICD-11: BA00 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0SJ4H | DIG Info | Beta-D-lactose | Diluent ... | ||
E0T2WF | DIG Info | Ferric oxide black | Colorant | ||
E0T4YW | DIG Info | Hypromellose | Coating agent | ||
E01UTP | DIG Info | Magnesium stearate | lubricant | ||
E0Q7IF | DIG Info | Povidone | Binding agent ... | ||
E0ST5E | DIG Info | Pregelatinized starch | Binding agent ... | ||
E0H6BT | DIG Info | Quinoline yellow WS | Colorant | ||
E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
E0K5HA | DIG Info | Simethicone | Antifoaming agent ... | ||
E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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G-protein coupled receptor (GPCR) | ||||||
DBT Name: Opioid receptor kappa (OPRK1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Simethicone | |||||
Biological Activity | IC50 = 155 nM (estimated based on the structural similarity with CHEMBL1707 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.942028986 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | OPRK_HUMAN | |||||
DBT Name: Opioid receptor mu (OPRM1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Simethicone | |||||
Biological Activity | IC50 = 1.5 nM (estimated based on the structural similarity with CHEMBL1707 ) | [1] | ||||
Structural Similarity | Tanimoto coefficient = 0.942028986 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | OPRM_HUMAN | |||||
DBT Name: Alpha-2A adrenoceptor (ADA2A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Quinoline yellow WS | |||||
Biological Activity | IC50 = 28 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ADA2A_HUMAN | |||||
DBT Name: Dopamine D3 receptor (DRD3) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Quinoline yellow WS | |||||
Biological Activity | IC50 = 26 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | DRD3_HUMAN | |||||
Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Magnesium stearate | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (4) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | IC50 = 107 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (5) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (6) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Silicon dioxide | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (7) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Pregelatinized starch | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (8) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Pregelatinized starch | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
DBT Name: Cytochrome P450 2E1 (CYP2E1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | IC50 = 253.5 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2E1_HUMAN | |||||
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | EC50 = 211.8 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2CJ_HUMAN | |||||
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | EC50 = 159.3 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2D6_HUMAN | |||||
DBT Name: Cytochrome P450 3A5 (CYP3A5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | IC50 = 19.4 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A5_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Acetylcholinesterase (ACHE) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Quinoline yellow WS | |||||
Biological Activity | IC50 > 10 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ACES_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | EC50 = 106.7 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | IC50 = 78.3 uM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Pregelatinized starch | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Dopamine transporter (DAT) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Quinoline yellow WS | |||||
Biological Activity | IC50 = 29 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SC6A3_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Estrogen receptor alpha (ESR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Quinoline yellow WS | |||||
Biological Activity | EC50 = 13156.33 nM (estimated based on the structural similarity with CHEMBL1417293 ) | [5] | ||||
Structural Similarity | Tanimoto coefficient = 0.828729282 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Quinoline yellow WS | |||||
Biological Activity | IC50 = 18 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Colon cancer Caco-2 cells (Caco-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | Promotion ratio > 18 % (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Hypromellose | |||||
Biological Activity | Promotion ratio > 27 % (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
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