Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0T2WF)
DIG Name	Ferric oxide black
Synonyms	Click to Show/Hide the Synonyms of This DIG Iron(II,III)oxide; Iron Oxide Black; Fe3O4; 12227-89-3; Iron(II,III) oxide, CP; oxoiron;oxo(oxoferriooxy)iron; IRON PIGMENT BLACK (E172); S350; Iron(II,III) oxide, powder, <5 mum, 95%; Iron(II,III) oxide, 99.99% trace metals basis; Q411235; Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size, 5 mg/mL in H2O; Iron(II,III) oxide, nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis; 120899-48-1; Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size, 5 mg/mL in H2O; Iron oxide(II,III), magnetic nanoparticles solution, 10 nm avg. part. size, 5 mg/mL in toluene; Iron oxide(II,III), magnetic nanoparticles solution, 10 nm diameter, biotin functionalized, 1 mg/mL Fe, dispersion in H2O; Iron oxide(II,III), magnetic nanoparticles solution, 20 nm avg. part. size, 5 mg/mL in H2O; Iron oxide(II,III), magnetic nanoparticles solution, 20 nm avg. part. size, 5 mg/mL in toluene; Iron oxide(II,III), magnetic nanoparticles solution, 30 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 30 nm avg. part. size (TEM), PEG functionalized, dispersion, 1 mg/mL Fe in H2O; Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size (TEM), biotin functionalized, 1 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H2O, dispersion; Iron oxide(II,III), magnetic nanoparticles solution, 5 nm avg. part. size, 5 mg/mL in toluene
DIG Function	Colorant
PubChem CID	16211978
Formula	Fe3O4
Canonical SMILES	O=[Fe].O=[Fe]O[Fe]=O
InChI	1S/3Fe.4O
InChIKey	SZVJSHCCFOBDDC-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=16211978"></iframe>
Structure	3D MOL is not available		2D MOL
Physicochemical Properties	Molecular Weight	231.53	Topological Polar Surface Area	60.4
	XlogP	N.A.	Complexity	36.2
	Heavy Atom Count	7	Rotatable Bond Count	0
	Hydrogen Bond Donor Count	0	Hydrogen Bond Acceptor Count	4

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01		Infectious/parasitic disease	Click to Show/Hide
Raltegravir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[1]
Saquinavir	API Info	Human immunodeficiency virus infection [ICD-11: 1C60]		[2]
Simeprevir	API Info	Viral hepatitis [ICD-11: 1E51]		[3]
ICD Disease Classification 02		Benign/in-situ/malignant neoplasm	Click to Show/Hide
Osimertinib	API Info	Lung cancer [ICD-11: 2C25]		[4]
Cabozantinib	API Info	Thyroid cancer [ICD-11: 2D10]		[5]
Niraparib	API Info	Ovarian cancer [ICD-11: 2C73]		[6]
Nilotinib	API Info	Chronic myelogenous leukaemia [ICD-11: 2A20]		[7]
Pazopanib	API Info	Renal cell carcinoma [ICD-11: 2C90]		[8]
ICD Disease Classification 03		Blood/blood-forming organ disease	Click to Show/Hide
Eltrombopag	API Info	Thrombocytopenia [ICD-11: 3B64]		[9]
ICD Disease Classification 05		Endocrine/nutritional/metabolic disease	Click to Show/Hide
Cysteamine	API Info	Nephropathic cystinosis [ICD-11: 5C60]		[10]
Trientine	API Info	Hyperphosphatemia [ICD-11: 5C64]		[11]
Ixazomib	API Info	Amyloidosis [ICD-11: 5D00]		[12]
ICD Disease Classification 06		Mental/behavioural/neurodevelopmental disorder	Click to Show/Hide
Cariprazine	API Info	Bipolar disorder [ICD-11: 6A60]		[13]
ICD Disease Classification 08		Nervous system disease	Click to Show/Hide
Hydromorphone	API Info	Anaesthesia [ICD-11: 8E22]		[14]
Pentosan polysulfate	API Info	Anaesthesia [ICD-11: 8E22]		[15]
Pimavanserin	API Info	Parkinsonism [ICD-11: 8A00]		[16]
ICD Disease Classification 11		Circulatory system disease	Click to Show/Hide
Disopyramide	API Info	Ventricular tachyarrhythmia [ICD-11: BC71]		[17]
Penbutolol	API Info	Essential hypertension [ICD-11: BA00]		[18]
Aliskiren	API Info	Essential hypertension [ICD-11: BA00]		[19]
Moexipril	API Info	Essential hypertension [ICD-11: BA00]		[20]
ICD Disease Classification 12		Respiratory system disease	Click to Show/Hide
Fexofenadine	API Info	Allergic rhinitis [ICD-11: CA08]		[21]
ICD Disease Classification 13		Digestive system disease	Click to Show/Hide
Naloxegol	API Info	Irritable bowel syndrome [ICD-11: DD91]		[22]
ICD Disease Classification 15		Musculoskeletal/connective-tissue disease	Click to Show/Hide
Cyclosporin A	API Info	Rheumatoid arthritis [ICD-11: FA20]		[23]

References
1	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
2	FDA label for approved saquinavir from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved simeprevir from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved osimertinib from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved cabozantinib from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved niraparib from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved nilotinib from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved pazopanib from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved eltrombopag from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved cysteamine from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved trientine from the official website of the U.S. Food and Drug Administration.
12	FDA label for approved ixazomib from the official website of the U.S. Food and Drug Administration.
13	FDA label for approved cariprazine from the official website of the U.S. Food and Drug Administration.
14	FDA label for approved hydromorphone from the official website of the U.S. Food and Drug Administration.
15	FDA label for approved pentosan polysulfate from the official website of the U.S. Food and Drug Administration.
16	FDA label for approved pimavanserin from the official website of the U.S. Food and Drug Administration.
17	FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
18	FDA label for approved penbutolol from the official website of the U.S. Food and Drug Administration.
19	FDA label for approved aliskiren from the official website of the U.S. Food and Drug Administration.
20	FDA label for approved moexipril from the official website of the U.S. Food and Drug Administration.
21	FDA label for approved fexofenadine from the official website of the U.S. Food and Drug Administration.
22	FDA label for approved naldemedine from the official website of the U.S. Food and Drug Administration.
23	FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.

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