General Information of DFM (ID: F07224)
Name	Enalapril 10 mg tablet
Company	RemedyRepack
Active Pharmaceutical Ingredient (API)	Enalapril		API Info click to show the detail info of this API
	Essential hypertension		ICD-11: BA00	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SJ4H	DIG Info	Beta-D-lactose	Diluent ...
	E09YYN	DIG Info	Eisenoxyd	Colorant
	E01UTP	DIG Info	Magnesium stearate	lubricant
	E0G1YW	DIG Info	Sodium bicarbonate	Alkalizing agent ...
	E0E8TN	DIG Info	Sodium stearate	Emulsifying agent ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
G-protein coupled receptor (GPCR)
DBT Name: Free fatty acid receptor 1 (FFAR1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	EC50 = 20892.96 nM (estimated based on the structural similarity with CHEMBL4281719 )					[1]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	FFAR1_HUMAN
DBT Name: Free fatty acid receptor 3 (FFAR3)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	EC50 = 100000 nM (estimated based on the structural similarity with CHEMBL3925414 )					[2]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Rattus norvegicus (Rat)
UniProt ID	FFAR3_RAT
DBT Name: Free fatty acid receptor 4 (FFAR4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	EC50 = 1698.24 nM (estimated based on the structural similarity with CHEMBL4281719 )					[1]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	FFAR4_HUMAN
DBT Name: GPCR84 receptor (GPR84)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	EC50 = 1700 nM (estimated based on the structural similarity with CHEMBL107874 )					[3]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	GPR84_HUMAN
Oxidoreductase (ORase)
DBT Name: Prostaglandin G/H synthase 1 (COX-1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 > 500000 nM (estimated based on the structural similarity with CHEMBL460025 )					[4]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Bos taurus (Bovine)
UniProt ID	PGH1_BOVIN
DBT Name: Prostaglandin G/H synthase 2 (COX-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 > 500000 nM (estimated based on the structural similarity with CHEMBL460025 )					[4]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Ovis aries (Sheep)
UniProt ID	PGH2_SHEEP
DBT Name: Albendazole monooxygenase (CYP3A4)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Magnesium stearate
Biological Activity	Protein expression downregulation (tested by experiment)					[5]
Tested Species	Homo sapiens (Human)
UniProt ID	CP3A4_HUMAN
Hydrolase (HDase)
DBT Name: Vaccinia H1 phosphatase (VHR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL1917282 )					[6]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	DUS3_HUMAN
Potential-driven transporter (PDT)
DBT Name: Organic anion transporter 6 (OAT6)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	Ki = 8128.31 nM (estimated based on the structural similarity with CHEMBL320358 )					[7]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Mus musculus (Mouse)
UniProt ID	S22AK_MOUSE
DBT Name: Organic anion transporter 1 (OAT1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	Ki = 33884.42 nM (estimated based on the structural similarity with CHEMBL1162491 )					[7]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Mus musculus (Mouse)
UniProt ID	S22A6_MOUSE
Transmembrane channel/porin (TC/P)
DBT Name: Vanilloid receptor 2 (TrpV2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 > 10000 nM (estimated based on the structural similarity with CHEMBL1173381 )					[8]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Rattus norvegicus (Rat)
UniProt ID	TRPV2_RAT
Nuclear receptor (NR)
DBT Name: PPAR-alpha (PPARA)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 = 30000 nM (estimated based on the structural similarity with CHEMBL1173381 )					[9]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	PPARA_HUMAN
DBT Name: PPAR-delta (PPARD)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 = 30000 nM (estimated based on the structural similarity with CHEMBL1173381 )					[9]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	PPARD_HUMAN
DBT Name: PPAR-gamma (PPARG)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 = 30000 nM (estimated based on the structural similarity with CHEMBL1173381 )					[9]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
UniProt ID	PPARG_HUMAN
Cell line (CELL)
DBT Name: Microglial BV-2 cells (BV-2)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sodium stearate
Biological Activity	IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL464787 )					[10]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Mus musculus (Mouse)
Cellosaurus ID	CVCL_0182

References
1	Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. Med Chem Comm. 2017; 8:1360-1365.
2	WO patent application no. 2001061359A2, NOVEL ASSAY.
3	An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem. 2020 Mar 12; 63(5):2391-2410.
4	Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001 Jun; 64(6):745-9.
5	Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6	Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6833-7.
7	Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.
8	Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists. J Med Chem. 2018 Sep 27; 61(18):8255-8281.
9	Molecular properties of fatty acids related to PPAR binding and metabolic diseases. Med Chem Res (2013) 22:3126-3133.
10	Natural neuro-inflammatory inhibitors from Caragana turfanensis. Bioorg Med Chem Lett. 2017 Oct 15; 27(20):4765-4769.

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