Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00237)
Name
Ergocalciferol
Synonyms    Click to Show/Hide the Synonyms of This API
ergocalciferol; VITAMIN D2; Calciferol; Viosterol; 50-14-6; Oleovitamin D2; Deltalin; Ercalciol; Ergorone; Sterogyl; Detalup; Drisdol; Condocaps; Crystallina; Fortodyl; Mulsiferol; Radsterin; Condol; Deratol; Diactol; Ertron; Geltabs; Novovitamin-D; Divit urto; D-Tracetten; Hi-Deratol; Calciferon 2; Dee-Ronal; Vitavel-D; D-Arthin; Dee-Ron; De-rat concentrate; Rodine C; Activated ergosterol; Calciferolum; Hyperkil; Rodinec; Mina D2; Viosterol in Oil; Radiostol; Ostelin; Haliver; Ergocalciferolum; Davitin; Metadee; Mykostin; (+)-Vitamin D2; Decaps; Infron; VitaminD2; Shock-ferol; Davitamon D; Dee-Osterol; Geltabs Vitamin D; Dee-Roual; Buco-D; Oleovitamin D, Synthetic; Uvesterol D; UNII-VS041H42XC; Vitamin D2 (Ergocalciferol); Ergosterol irradiated; Irradiated ergosterol; Oleovitamin D; CHEBI:28934; Irradiated ergosta-5,7,22-trien-3-beta-ol; Synthetic Vitamin D; Condacaps; Viostdrol; Crtron; 9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol; VS041H42XC; Uvesterol-D; (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol; (5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol; Ergosterol activated; MFCD00166988; Ergocalciferols; DSSTox_CID_233; (3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; DSSTox_RID_75449; DSSTox_GSID_20233; Ergocalciferolo; Disdrol; Radstein; VD2-D3; Ergocalciferolo [DCIT]; (5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; SMR000857106; Ergocalciferolum [INN-Latin]; Vitamin D 2; Shock-ferol sterogyl; HSDB 819; Sorex C.R.; EINECS 200-014-9; NSC 62792; Doral [Vitamin Derivative]; Osteil; delta-Tracetten; delta-Arthin; beta-ol; NSC-62792; D-forte; 9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol, (3.beta.,5Z,7E,22E)-; ergocalciferol oil; Eciferol D2; Vitamina D2; Calciferol (TN); CAS-50-14-6; Ergoral D2; NCGC00166307-01; Sterogyl-15; ergocalciferol group; Sterogyl 15H; Prestwick_554; Drisdol (TN); Ergocalciferol [USP:INN:BAN:JAN]; Vitamin D2 solution; Ergo-D2; Osto-D2; vitamin D2 derivatives; PubChem16654; Calciferol In Arach Oil; 9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol; Prestwick3_000420; bmse000510; (3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol; SCHEMBL3420; CHEMBL1536; ergocalciferol; 50-14-6; BSPBio_000380; Ergocalciferol (JP17/USP); MLS001332467; MLS001332468; BPBio1_000418; MEGxm0_000466; DTXSID5020233; ACon1_002187; HMS2096C22; HMS2230E20; 1217448-46-8; ACT02622; CS-M1019; ZINC4629876; Tox21_112404; Tox21_202348; Tox21_302752; BDBM50247883; LMST03010001; Vitamin D2; Ergocalciferol; Deltalin; 9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol, (3beta,5Z,7E,22E)-; AKOS022185284; CCG-268614; DB00153; Ergocalciferol, Sigma Reference Standard; NCGC00166307-02; NCGC00166307-03; NCGC00256529-01; NCGC00259897-01; AS-11649; Ergocalciferol (D2), analytical standard; HY-76542; Irradiated ergosta-5,7,22-trien-3beta-ol; Vitamin D2 Ergocalciferol 400,000 IU/g; Ergocalciferol, 40,000,000 USP units/g; 7067-EP2305662A1; C05441; D00187; 166V988; Q139200; Q-201930; 9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol; Ergocalciferol, >=98.0% (sum of enantiomers, HPLC); 22-tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol; 7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87; UNII-9VU1KI44GP component MECHNRXZTMCUDQ-RKHKHRCZSA-N; Vitamin D2 solution, 100 mug/mL in ethanol, 98% (CP); (5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol; Ergocalciferol, British Pharmacopoeia (BP) Reference Standard; Ergocalciferol, European Pharmacopoeia (EP) Reference Standard; Ergocalciferol, United States Pharmacopeia (USP) Reference Standard; (3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol; Vitamin D2. Short expiry date due to chemical nature of component(s)
Clinical Status
Approved
Disease Indication Hypoparathyroidism ICD-11: 5A50 [1]
PubChem CID
5280793
Formula
C28H44O
Canonical SMILES
C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C
InChI
1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1
InChIKey
MECHNRXZTMCUDQ-RKHKHRCZSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5280793"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 396.6 Topological Polar Surface Area 20.2
XlogP 7.4 Complexity 678
Heavy Atom Count 29 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Ergocalciferol 50000 unt capsule Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Sodium lauryl sulfate; Butylparaben; D&c yellow no. 10; Benzyl alcohol; Fd&c blue no. 1; Propylparaben; Polysorbate 80; Gelatin; Soybean oil
                   Dosage Form Oral Capsule
                   Company AvKARE; Carilion Materials Management; Clinical Solutions Wholesale; Proficient Rx; ReadyMeds; Rising Pharmaceuticals; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [3]
Benzyl alcohol DIG Info Indoleamine 2,3-dioxygenase 1 (IC50 = 1400 nM) [4]
Butylparaben DIG Info Estrogen receptor alpha (IC50 = 1420 nM) [5]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Butyl alcohol; Fd&c blue no. 1; Isopropyl alcohol; Ammonia; Glycerin; Propylene glycol; Titanium dioxide; Water; Dimethicone; Gelatin; Shellac; Soybean oil
                   Dosage Form Oral Capsule
                   Company A-S Medication Solutions; Aphena Pharma Solutions-Tennessee; Bryant Ranch Prepack; PD-Rx Pharmaceuticals; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [7]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Butyl alcohol; Fd&c blue no. 1; Isopropyl alcohol; Ammonia; Glycerin; Propylene glycol; Titanium dioxide; Water; Dimethicone; Gelatin, unspecified; Shellac; Soybean oil
                   Dosage Form Oral Capsule
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [7]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [8]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 5; Ethylene glycol monoethyl ether; Glycerin; Titanium dioxide; Water; Lecithin, soybean; Medium-chain triglycerides; Gelatin; Shellac; Soybean oil
                   Dosage Form Oral Capsule
                   Company Aidarex Pharmaceuticals; Avera McKennan Hospital; Paddock Laboratories,; Proficient Rx; RemedyRepack; Strides Shasun
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [6]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [8]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [9]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c yellow no. 5; Ethylene glycol monoethyl ether; Glycerin; Titanium dioxide; Water; Lecithin, soybean; Medium-chain triglycerides; Gelatin, unspecified; Shellac; Soybean oil
                   Dosage Form Oral Capsule
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [6]
Soybean lecithin DIG Info Albendazole monooxygenase (IC50 = 6.61 mg.mL-1) [8]
Medium-chain triglyceride DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 36 %) [9]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c blue no. 1; Glycerin; Water; Gelatin; Soybean oil
                   Dosage Form Oral Capsule
                   Company Aidarex Pharmaceuticals; Blenheim Phamacal; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c blue no. 1; Glycerin; Water; Gelatin, unspecified; Soybean oil
                   Dosage Form Oral Capsule
                   Company American Health Packaging; PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c blue no. 1; Glycerin; Water; Gelatin; Soybean oil
                   Dosage Form Oral Capsule
                   Company AvKARE; Banner Life Sciences; Bionpharma; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals; Pliva; RemedyRepack; St Marys Medical Park Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [6]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Fd&c yellow no. 5; Glycerin; Gelatin; Soybean oil
                   Dosage Form Oral Capsule
                   Company Validus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [6]
          Ergocalciferol 1.25 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Fd&c yellow no. 5; Glycerin; Gelatin; Soybean oil
                   Dosage Form Oral Capsule
                   Company Sanofi-Aventis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Hydrazine yellow DIG Info GABA(A) receptor alpha-1 (IC50 = 13 uM) [6]
References
1 FDA label for approved ergocalciferol from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.
4 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
5 Disconnecting the Estrogen Receptor Binding Properties and Antimicrobial Properties of Parabens through 3,5-Substitution. ACS Med Chem Lett. 2017 Dec 15; 9(1):51-55.
6 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
7 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
8 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
9 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.