Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00603)
Name
Rizatriptan
Synonyms    Click to Show/Hide the Synonyms of This API
rizatriptan; 144034-80-0; Risatriptan; MK 462 free base; 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine; N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine; 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-; UNII-51086HBW8G; N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine; CHEMBL905; CHEBI:48273; 51086HBW8G; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine; NCGC00095899-01; Rizatriptan [INN:BAN]; DIMETHYL({2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHYL})AMINE; Rizatriptan benzoat; rizatriptanum; Rizatriptan (INN); PubChem16714; DSSTox_CID_3565; GTPL51; DSSTox_RID_77082; DSSTox_GSID_23565; MK-462 FREE BASE; SCHEMBL26662; cc-317; MLS006010229; BIDD:GT0361; SPECTRUM1505189; ORPHENADRINEHYDROCHLORIDE; IND062; ZINC5895; DTXSID2023565; BCP28039; Tox21_111534; BDBM50033437; MFCD03840591; STL484039; AKOS015896596; AC-1712; DB00953; NCGC00095899-04; NCGC00095899-09; NCGC00095899-15; AK-72890; BR-72890; DS-15263; SMR000469172; SBI-0206745.P001; DB-080717; CAS-144034-80-0; FT-0704226; D08485; S-5530; AB00698277-05; AB00698277-07; AB00698277_08; AB00698277_09; 034R800; A808161; L000812; Q212171; Q-201675; BRD-K75699339-057-03-2; 4-(1H-1,2,4-Triazole-1-yl-methyl)anilinehydrochloride; Dimethyl-[2-(5-[1,2,4]triazol-1-ylmethyl-1H-indol-3-yl)-ethyl]-amine; N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl] ethylamine
Clinical Status
Approved
Disease Indication Migraine ICD-11: 8A80 [1]
PubChem CID
5078
Formula
C15H19N5
Canonical SMILES
CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3
InChI
1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3
InChIKey
ULFRLSNUDGIQQP-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5078"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 269.34 Topological Polar Surface Area 49.7
XlogP 1.7 Complexity 309
Heavy Atom Count 20 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Rizatriptan 10 mg tablet Click to Show/Hide the Full List of Formulation(s):        30 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Menthol; Sodium stearyl fumarate; Aspartame; Isopropyl alcohol; Mannitol; Anhydrous dibasic calcium phosphate; Xylitol; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose
                   Dosage Form Disintegrating Oral Tablet
                   Company Bionpharma; Panacea Biotec
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Menthol DIG Info Transient receptor potential p8 (EC50 = 3000 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [6]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glycine; Aspartame; Magnesium stearate; Mannitol; Sodium chloride; Monosodium citrate; Croscarmellose sodium; Crospovidone; Cellulose, microcrystalline; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Breckenridge Pharmaceutical; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Aminoethanoic acid DIG Info Glycine type-1 transporter (IC50 = 31600 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glycine; Aspartame; Magnesium stearate; Mannitol; Sodium chloride; Monosodium citrate; Croscarmellose sodium; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Aminoethanoic acid DIG Info Glycine type-1 transporter (IC50 = 31600 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Calcium silicate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Disintegrating Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Sorbitol; Crospovidone; Silicon dioxide; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Mannitol; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Orange
                   Dosage Form Disintegrating Oral Tablet
                   Company Unichem Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acesulfame potassium; Sodium stearyl fumarate; Mannitol; Crospovidone; Silicon dioxide; Ethylcelluloses; Hypromelloses; Peppermint; Strawberry
                   Dosage Form Disintegrating Oral Tablet
                   Company Jubilant Cadista Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Acesulfame DIG Info Carbonic anhydrase IX (Ki = 2400 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Sorbitol; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Aspartame; Mannitol; Crospovidone; Cellulose, microcrystalline; Peppermint; Starch, corn
                   Dosage Form Disintegrating Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%)
                   Dosage Form Disintegrating Oral Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Mannitol; Crospovidone; Cellulose, microcrystalline; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Apotex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Mannitol; Crospovidone; Cellulose, microcrystalline; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Carboxymethylcellulose calcium; Cellulose, microcrystalline; Colloidal silicon dioxide; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Macleods Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Mannitol; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Glenmark Pharmaceutials; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Cipla
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Exelan Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Apotex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cipla
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical; Medsource Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Macleods Pharmaceuticals; Stat Rx USA; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 27 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 28 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Unichem Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 29 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Ascend Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 30 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
          Rizatriptan 5 mg tablet Click to Show/Hide the Full List of Formulation(s):        25 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Menthol; Sodium stearyl fumarate; Aspartame; Isopropyl alcohol; Mannitol; Anhydrous dibasic calcium phosphate; Xylitol; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose
                   Dosage Form Disintegrating Oral Tablet
                   Company Bionpharma; Panacea Biotec
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Menthol DIG Info Transient receptor potential p8 (EC50 = 3000 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [6]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glycine; Aspartame; Magnesium stearate; Mannitol; Sodium chloride; Monosodium citrate; Croscarmellose sodium; Crospovidone; Cellulose, microcrystalline; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Breckenridge Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Aminoethanoic acid DIG Info Glycine type-1 transporter (IC50 = 31600 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Calcium silicate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Disintegrating Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Mannitol; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Orange
                   Dosage Form Disintegrating Oral Tablet
                   Company Unichem Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Acesulfame potassium; Sodium stearyl fumarate; Mannitol; Crospovidone; Silicon dioxide; Ethylcelluloses; Hypromelloses; Peppermint; Strawberry
                   Dosage Form Disintegrating Oral Tablet
                   Company Jubilant Cadista Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Acesulfame DIG Info Carbonic anhydrase IX (Ki = 2400 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Sorbitol; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Aspartame; Mannitol; Crospovidone; Cellulose, microcrystalline; Peppermint; Starch, corn
                   Dosage Form Disintegrating Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Silicon dioxide; Cellulose, microcrystalline; Crospovidone (15 mpa.s at 5%)
                   Dosage Form Disintegrating Oral Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucralose; Magnesium stearate; Mannitol; Crospovidone; Cellulose, microcrystalline; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Apotex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sucralose DIG Info Carbonic anhydrase II (Ki = 300 nM) [9]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glycine; Aspartame; Mannitol; Gelatin
                   Dosage Form Disintegrating Oral Tablet
                   Company Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Aminoethanoic acid DIG Info Glycine type-1 transporter (IC50 = 31600 nM) [8]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Aspartame; Magnesium stearate; Mannitol; Carboxymethylcellulose calcium; Cellulose, microcrystalline; Colloidal silicon dioxide; Peppermint
                   Dosage Form Disintegrating Oral Tablet
                   Company Macleods Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Cipla
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Silicon dioxide; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Exelan Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Crospovidone; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sandoz
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Apotex
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cipla
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Heritage Pharmaceuticals; Macleods Pharmaceuticals; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Colloidal silicon dioxide; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Unichem Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company Ascend Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
References
1 FDA label for approved rizatriptan from the official website of the U.S. Food and Drug Administration.
2 Serendipity in drug-discovery: a new series of 2-(benzyloxy)benzamides as TRPM8 antagonists. Bioorg Med Chem Lett. 2013 Nov 15; 23(22):6118-22.
3 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
4 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
5 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
6 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
7 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
8 Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. Bioorg Med Chem Lett. 2014 Feb 15; 24(4):1067-70.
9 Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose. ACS Med Chem Lett. 2018 May 10; 9(7):657-661.

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