Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00315)
Name
Hydromorphone
Synonyms    Click to Show/Hide the Synonyms of This API
hydromorphone; Dihydromorphinone; Dimorphone; Hydromorphon; Idromorfone; Laudacon; 7,8-Dihydromorphinone; Dihydromorfinon; Hydromorfona; Novolaudon; Dilaudid; Dilaudid Oros; 466-99-9; Hydromorfona [Spanish]; Dihydromorfinon [Czech]; Hidromorfona; Hydromorphonum; Palladone; Hidromorfona [INN-Spanish]; Hydromorphonum [INN-Latin]; 6-Deoxy-7,8-dihydro-6-oxomorphine; Dilaudid-hp; 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one; 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone; (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one; Morphinone, dihydro-; UNII-Q812464R06; CHEBI:5790; CHEMBL398707; (-)-Hydromorphone; 3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one; NSC-19046; DEA No. 9150; Idromorfone [DCIT]; Laudicon; NSC 19046; Q812464R06; (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one; Hydromorphone [INN:BAN]; Hydromorphone (INN); HSDB 3341; EINECS 207-383-5; Morphinan-6-one, 4,5-epoxy-3-hydroxy-17-methyl-, (5alpha)-; N02AA03; Hydromorphone form I; (5alpha)-3-hydroxy-17-methyl-4,5-epoxymorphinan-6-one; Hydromorphone Form II; Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-17-methyl-; SCHEMBL2255; GTPL7082; IDS-NH-004; DTXSID8023133; ZINC402954; NSC19046; BDBM50241341; Hydromorphone 0.1 mg/ml in Methanol; Hydromorphone 1.0 mg/ml in Methanol; DB00327; C07042; D08047; Q303646; Morphinan-6-one,5.alpha.-epoxy-3-hydroxy-17-methyl-; Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl- (8CI); Morphinan-6-one,5-epoxy-3-hydroxy-17-methyl-, (5.alpha.)-; WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JQ P1; Hydromorphone solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material; (1S,5R,13R,17R)-10-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one; (4R,4aR,7aR,12bS)-9-hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one; (4R,4aR,7aR,12bS)-9-Hydroxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one]
Clinical Status
Approved
Disease Indication Anaesthesia ICD-11: 8E22 [1]
PubChem CID
5284570
Formula
C17H19NO3
Canonical SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3C(=O)CC4
InChI
1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1
InChIKey
WVLOADHCBXTIJK-YNHQPCIGSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5284570"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 285.34 Topological Polar Surface Area 49.8
XlogP 1.8 Complexity 494
Heavy Atom Count 21 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Hydromorphone 12 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 1; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polyethylene glycol 400; Polysorbate 80; Povidone k30; Silicon dioxide; Ammonio methacrylate copolymer type a; Cellulose, microcrystalline; Ethylcellulose (100 mpa.s); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Polyethylene glycol 3350; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Sodium chloride; Talc; Titanium dioxide; Cellulose acetate; Copovidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Silicon dioxide; Cellulose acetate; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (5 mpa.s); Polyethylene glycol 7000000; Polyethylene glycols; Polyethylene oxide 200000
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Trigen Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Hydromorphone 32 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Magnesium stearate; Mannitol; Ferric oxide red; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polyethylene glycol 400; Povidone k30; Silicon dioxide; Ammonio methacrylate copolymer type a; Cellulose, microcrystalline; Ethylcellulose (100 mpa.s); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Polyethylene glycol 3350; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferrosoferric oxide; Propylene glycol; Sodium chloride; Talc; Titanium dioxide; Cellulose acetate; Copovidone; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Silicon dioxide; Cellulose acetate; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (5 mpa.s); Polyethylene glycol 7000000; Polyethylene glycols; Polyethylene oxide 200000
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Trigen Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Hydromorphone 8 mg tablet Click to Show/Hide the Full List of Formulation(s):        17 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 1; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polyethylene glycol 400; Povidone k30; Silicon dioxide; Ammonio methacrylate copolymer type a; Cellulose, microcrystalline; Ethylcellulose (100 mpa.s); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Polyethylene glycol 3350; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Lactose, anhydrous; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Povidone; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c red no. 40; Magnesium stearate; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Silicon dioxide; Cellulose acetate; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (5 mpa.s); Polyethylene glycol 7000000; Polyethylene glycols; Polyethylene oxide 200000
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Trigen Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [4]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company SpecGx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Propylene glycol; Sodium chloride; Talc; Titanium dioxide; Cellulose acetate; Copovidone; Hypromelloses; Polyethylene glycols; Polyvinyl alcohol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Aurolife Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Precision Dose
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company TAGI Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Rhodes Pharmaceuticals; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Hydromorphone 16 mg tablet Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Fd&c blue no. 1; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polyethylene glycol 400; Povidone k30; Silicon dioxide; Ammonio methacrylate copolymer type a; Cellulose, microcrystalline; Ethylcellulose (100 mpa.s); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Paddock Laboratories,
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Fd&c yellow no. 6; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Silicon dioxide; Cellulose acetate; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (5 mpa.s); Polyethylene glycol 7000000; Polyethylene glycols; Polyethylene oxide 200000
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Trigen Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Polyethylene glycol 3350; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Polyethylene glycol 3350 DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Mallinckrodt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Butylated hydroxytoluene; Magnesium stearate; Ferric oxide yellow; Ferrosoferric oxide; Sodium chloride; Titanium dioxide; Triacetin; Cellulose acetate; Hypromellose 2910 (5 mpa.s); Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Propylene glycol; Sodium chloride; Talc; Titanium dioxide; Cellulose acetate; Copovidone; Hypromelloses; Polyethylene glycols; Polyvinyl alcohol, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Hydromorphone 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          8 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Aurolife Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [7]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [7]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Rhodes Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [7]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [7]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c red no. 30; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
D&C red no. 30 DIG Info Heat shock factor 1 (EC50 = 9054 nM) [7]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company SpecGx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Lannett Company; PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Hydromorphone 4 mg tablet Click to Show/Hide the Full List of Formulation(s):          9 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Aurolife Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Rhodes Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; D&c yellow no. 10; Magnesium stearate; Sodium metabisulfite
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Lake Eire Medical & Surgical Supply DBA Quality Care Products; McKesson; Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care; Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company SpecGx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate
                   Dosage Form Oral Tablet
                   Company West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Hydromorphone 24 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 2; Titanium dioxide; Synthetic black iron oxide; Ammonio methacrylate copolymer type b; Ethylcellulose; Steryl alcohol
                   Dosage Form 24 HR Extended Release Capsule
                   Company Purdue Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
          Hydromorphone 12 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Titanium dioxide; Synthetic black iron oxide; Ammonio methacrylate copolymer type b; Ethylcellulose; Gelatin; Red iron oxide; Steryl alcohol
                   Dosage Form 24 HR Extended Release Capsule
                   Company Purdue Pharma
          Hydromorphone 16 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Titanium dioxide; Synthetic black iron oxide; Ammonio methacrylate copolymer type b; Ethylcellulose; Gelatin; Red iron oxide; Steryl alcohol
                   Dosage Form 24 HR Extended Release Capsule
                   Company Purdue Pharma
          Hydromorphone 32 mg capsule Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Titanium dioxide; Synthetic black iron oxide; Ammonio methacrylate copolymer type b; Ethylcellulose; Steryl alcohol
                   Dosage Form 24 HR Extended Release Capsule
                   Company Purdue Pharma
References
1 FDA label for approved hydromorphone from the official website of the U.S. Food and Drug Administration.
2 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
3 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
4 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
7 PubChem BioAssay data set.
8 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15; 17(8):3207-11.
9 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.

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