Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00374)
Name
Loratadine
Synonyms    Click to Show/Hide the Synonyms of This API
loratadine; 79794-75-5; Claritin; Loratidine; Alavert; Clarityn; Lisino; Clarityne; Loracert; Loradex; Bonalerg; Claritine; Fristamin; Histaloran; Lertamine; Lorastine; Civeran; Loranox; Versal; Sch 29851; Anhissen; Sch-29851; UNII-7AJO3BO7QN; MFCD00672869; C22H23ClN2O2; Loratyne; Allertidin; Claratyne; Polaratyne; Restamine; Aerotina; Alerpriv; Biloina; Lesidas; Loradif; Lorantis; Loraver; Lorfast; Loritine; Lowadina; Nularef; Optimin; Sanelor; Sensibit; Sohotin; Velodan; 7AJO3BO7QN; Tadine; CHEMBL998; Sinhistan Dy; Bedix Loratadina; Talorat Dy; Claritin Reditabs; Clarinase Reperabs; MLS000069647; Loratadinum [Latin]; Claritin reditab; Loratadina [Spanish]; Clarityne-D; Children's Claritin; NCGC00015619-09; Loratadinum; Loratadina; SMR000058255; Clarityne Dy Repetabs; DSSTox_CID_3224; DSSTox_RID_76931; DSSTox_GSID_23224; Loratadine Redidose; Claritin Hives Relief; Bactimicina allergy; Claritin (TN); Claritin Hives Relief Reditab; CAS-79794-75-5; HSDB 3578; SR-01000075968; Cronopen; Flonidan; Klaritin; loratadine-form1; Topcare childrens allergy relief; LoratadineI-p25; Loratadine,(S); Loratadine [USAN:USP:INN:BAN]; loratadine-form2-He; Spectrum_001496; Tocris-1944; LoratadineI-0deg(L13); Opera_ID_1868; Spectrum2_001584; Spectrum3_000740; Spectrum4_000177; Spectrum5_001650; Lopac-L-9664; LoratadineI-p80(L13); L 9664; LoratadineI-m100(L13); LoratadineI-m173(L13); SCHEMBL4596; Lopac0_000680; Oprea1_027965; REGID_for_CID_3957; BSPBio_002300; KBioGR_000693; KBioSS_001976; Loratadine (JAN/USP/INN); MLS000758260; MLS001148466; MLS001423984; BIDD:GT0198; DivK1c_000792; SPECTRUM1503712; SPBio_001548; CHEBI:6538; GTPL7216; DTXSID2023224; BDBM22876; HMS502H14; KBio1_000792; KBio2_001976; KBio2_004544; KBio2_007112; KBio3_001520; NINDS_000792; HMS2051G11; HMS2090O18; HMS2093I15; HMS2235G23; HMS3262G21; HMS3268M16; HMS3371D13; HMS3393G11; HMS3412N06; HMS3654L17; HMS3676N06; HMS3714E09; Pharmakon1600-01503712; ZINC537931; Loratadine 0.1 mg/ml in Methanol; ACT04775; BCP22338; Tox21_110185; Tox21_301532; Tox21_500680; BBL010757; CCG-39362; CL0028; DL-436; HTS028367; NSC721075; NSC758628; STK574925; AKOS005499513; Loratadine (Desloratadine Impurity E); Loratadine, >=98% (HPLC), powder; Tox21_110185_1; AB06849; AC-2086; BAY76-2211; BCP9000858; CCG-100786; CS-0887; DB00455; KS-1079; LP00680; MCULE-5073177964; NC00036; NSC-721075; NSC-758628; SDCCGSBI-0050659.P004; IDI1_000792; NCGC00015619-01; NCGC00015619-02; NCGC00015619-03; NCGC00015619-04; NCGC00015619-05; NCGC00015619-06; NCGC00015619-07; NCGC00015619-08; NCGC00015619-10; NCGC00015619-11; NCGC00015619-12; NCGC00015619-13; NCGC00015619-26; NCGC00023125-02; NCGC00023125-04; NCGC00023125-05; NCGC00023125-06; NCGC00023125-07; NCGC00255171-01; NCGC00261365-01; AK-88666; HY-17043; NCI60_041473; SY052751; BCP0726000007; SBI-0050659.P003; AB0012486; EU-0100680; FT-0627976; SW197416-3; D00364; J10034; M-5196; AB00053224-15; AB00053224-16; AB00053224_17; AB00053224_18; 794L755; L000667; Q424049; Q-100833; SR-01000075968-1; SR-01000075968-3; SR-01000075968-4; SR-01000075968-6; BRD-K82795137-001-02-3; BRD-K82795137-001-10-6; Z1741979837; Loratadine, British Pharmacopoeia (BP) Reference Standard; Loratadine, European Pharmacopoeia (EP) Reference Standard; Loratadine, United States Pharmacopeia (USP) Reference Standard; Loratadine, Pharmaceutical Secondary Standard; Certified Reference Material
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
3957
Formula
C22H23ClN2O2
Canonical SMILES
CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
InChI
1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
InChIKey
JCCNYMKQOSZNPW-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3957"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 382.9 Topological Polar Surface Area 42.4
XlogP 5.2 Complexity 569
Heavy Atom Count 27 Rotatable Bond Count 2
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Loratadine 10 mg tablet Click to Show/Hide the Full List of Formulation(s):        32 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Maltodextrin; Ascorbic acid; Aspartame; Magnesium stearate; Mannitol; Ferric oxide red; Sodium bicarbonate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Disintegrating Tablet
                   Company Pfizer Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [6]
Ascorbic acid DIG Info Albendazole monooxygenase (IC50 = 4.1 mg.mL-1) [7]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Maltodextrin; Aspartame; Magnesium stearate; Mannitol; Butylated hydroxyanisole; Ferric oxide red; Sodium bicarbonate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Corn syrup; Icodextrin
                   Dosage Form Disintegrating Tablet
                   Company Pfizer Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Maltodextrin; Aspartame; Magnesium stearate; Mannitol; Butylated hydroxyanisole; Ferric oxide red; Sodium bicarbonate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Corn syrup; Icodextrin
                   Dosage Form Disintegrating Oral Tablet
                   Company Pfizer Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Dextrin DIG Info Colon cancer Caco-2 cells (Inhibition ratio > 55 %) [6]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Sodium stearate; Lactose monohydrate; Sodium lauryl sulfate; Aspartame; Mannitol; Crospovidone; Povidone; Cellulose, microcrystalline; Colloidal silicon dioxide
                   Dosage Form Disintegrating Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearate DIG Info Free fatty acid receptor 4 (EC50 = 1698.24 nM) [9]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [8]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Aspartame; Magnesium stearate; Mannitol; Sodium bicarbonate; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Corn syrup
                   Dosage Form Disintegrating Oral Tablet
                   Company Pfizer Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Hypromellose; Povidone; Silicon dioxide; Cellulose, microcrystalline; Starch, corn
                   Dosage Form 24 HR Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [8]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [10]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Aspartame; Magnesium stearate; Mannitol; Croscarmellose sodium
                   Dosage Form Disintegrating Oral Tablet
                   Company American Sales Company; CVS Pharmacy; Chain Drug Consortium; Chain Drug Marketing Association; Fred's; Good Neighbor Pharmacy; Health Mart; Major Pharmaceuticals; Meijer; Safeway; Select Brand; Shopko; Sunmark; SuperValu; Target Corporation; TopCare; Topco Associates; Valu Merchandisers Company; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [11]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Aspartame; Magnesium stearate; Mannitol; Croscarmellose sodium
                   Dosage Form Disintegrating Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [11]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearyl fumarate; Aspartame; Magnesium stearate; Mannitol; Croscarmellose sodium
                   Dosage Form Disintegrating Oral Tablet
                   Company Ohm Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [11]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Povidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [8]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium lauryl sulfate; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Mannitol; Gelatin
                   Dosage Form Disintegrating Oral Tablet
                   Company Bayer HealthCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Marc Glassman, Inc.; Selder, S.A. de C.V.
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Allegiant Health; Apotex; AvPAK; Blenheim Phamacal; Cardinal Health; DLC Laboratories; Gericare Pharmaceuticals; Major Pharmaceuticals; NuCare Pharmaceuticals; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidone; Starch, corn
                   Dosage Form Oral Tablet
                   Company DirectRX; H. J. Harkins Company; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Melaleuca; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidone; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company International Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidone
                   Dosage Form Oral Tablet
                   Company McKesson; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidone; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Novartis Consumer Health; Target Brands
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Novartis Consumer Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Contract Pharmacal; Health Mart; Innovative Manufacturing and Distribution Services; Lake Eire Medical & Surgical Supply DBA Quality Care Products; McKesson; NCS HealthCare of KY, Inc dba Vangard Labs; NorthStar Rx; NuCare Pharmaceuticals; Physicians Total Care; RemedyRepack; Sandoz; St Marys Medical Park Pharmacy; State of Florida DOH Central Pharmacy; Sunmark; Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Proficient Rx; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidones; Starch, corn
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack; Cardinal Health; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Povidones
                   Dosage Form Oral Tablet
                   Company 7-Eleven; American Sales Company; Amerisource Bergen; Aphena Pharma Solutions-Tennessee; Army & Air Force Exchange Service; BJWC; Big Lots Stores; CVS Pharmacy; Cardinal Health; Costco Wholesale; DZA Brands; Dolgencorp; Family Dollar; First Aid Direct; Greenbrier International; Harmon Stores; Harris Teeter; Humana Pharmacy; Hy-Vee; Kinray; Kmart Corporation; Kroger Company; L. Perrigo Company; Major Pharmaceuticals; McKesson; Meijer; NuCare Pharmaceuticals; Perrigo New York; Preferred Pharamaceuticals; Procter & Gamble Manufacturing Company; RemedyRepack; Rite Aid; Safeway; Sam's West; Save-A-Lot Food Stores; Shopko; SuperValu; Target Corporation; Topco Associates; Wakefern Food Corporation; Wal-Mart Stores; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
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Lactose monohydrate; Magnesium stearate; Starch, corn; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Medicine Shoppe International
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 27 DFM Info click to show the detail info of this DFM
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Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Moore Medical; Unifirst First Aid
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 28 DFM Info click to show the detail info of this DFM
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Lactose; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company Select Corporation
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 29 DFM Info click to show the detail info of this DFM
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Lactose monohydrate; Magnesium stearate; Starch, corn; Starch, corn
                   Dosage Form Oral Tablet
                   Company Help Remedies; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 30 DFM Info click to show the detail info of this DFM
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Lactose monohydrate; Magnesium stearate; Starch, corn; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company Amerisource Bergen; Cardinal Health; Chain Drug Marketing Association; Family Dollar; Fred's; Major Pharmaceuticals; Medline Industries; Publix Super Markets; Select Brand; Shopko; Valu Merchandisers Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 31 DFM Info click to show the detail info of this DFM
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Lactose monohydrate; Magnesium stearate; Starch, corn; Starch, pregelatinized corn
                   Dosage Form Oral Tablet
                   Company SuperValu
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 32 DFM Info click to show the detail info of this DFM
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Lactose monohydrate; Magnesium stearate; Starch, corn
                   Dosage Form Oral Tablet
                   Company American Health Packaging; Bayer HealthCare; CVS Pharmacy; Cardinal Health; Clinical Solutions Wholesale; Contract Pharmacal; DLC Laboratories; Kaiser Foundation Hospitals; Kinray; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Major Pharmaceuticals; Mylan Pharamceuticals; Navajo Manufacturing; NuCare Pharmaceuticals; Ohm Laboratories; Premier Value; Proficient Rx; Safeway; TYA Pharmaceuticals; Walgreens Company; WinCo Foods
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Loratadine 5 mg tablet Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Stearic acid; Aspartame; D&c red no. 27; Fd&c blue no. 2; Magnesium stearate; Mannitol; Silicon dioxide; Aluminum oxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Chewable Tablet
                   Company Bayer HealthCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [8]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; Stearic acid; Aspartame; D&c red no. 27; Fd&c blue no. 2; Magnesium stearate; Mannitol; Silicon dioxide; Aluminum oxide; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company MSD Consumer Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [8]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
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Stearic acid; Aspartame; Magnesium stearate; Mannitol; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Chewable Tablet
                   Company Bayer HealthCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [4]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
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Anhydrous citric acid; Mannitol; Gelatin
                   Dosage Form Disintegrating Oral Tablet
                   Company Bayer HealthCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [2]
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [3]
          Loratadine 10 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Capric acid; Fd&c blue no. 1; Sorbitol; Water; Polysorbate 80; Povidone k30; Gelatin; Sorbitan
                   Dosage Form Oral Capsule
                   Company Marksans Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [8]
Caprylic acid DIG Info GPCR84 receptor (Ki = 19600 nM) [12]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Sorbitol; Water; Polysorbate 80; Povidone; Caprylic/capric mono/diglycerides; Gelatin
                   Dosage Form Oral Capsule
                   Company CVS Pharmacy; Cardinal Health; KMART; Kroger Company; Time Cap Labs; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [8]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [10]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Sorbitol; Glycerin; Water; Polysorbate 80; Gelatin; Povidones
                   Dosage Form Oral Capsule
                   Company Bayer HealthCare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [8]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [4]
References
1 FDA label for approved loratadine from the official website of the U.S. Food and Drug Administration.
2 PubChem BioAssay data set.
3 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
4 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Interactions between human multidrug resistance related protein (MRP2; ABCC2) and excipients commonly used in self-emulsifying drug delivery systems (SEDDS). Int J Pharm. 2013 Apr 15;447(1-2):192-8.
7 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
8 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
9 Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. Med Chem Comm. 2017; 8:1360-1365.
10 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
11 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
12 An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. J Med Chem. 2020 Mar 12; 63(5):2391-2410.

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