Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00205)
Name
Disopyramide
Synonyms    Click to Show/Hide the Synonyms of This API
disopyramide; Rythmodan; Dicorantil; Ritmodan; Disopiramida; Searle 703; Disopyramidum; Disopyramidum [INN-Latin]; Disopiramida [INN-Spanish]; SC 7031; alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide; SC-7031; gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide; H 3292; CHEMBL517; alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide; 2-Pyridineacetamide, alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-; CHEBI:4657; 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide; 3737-09-5 (free base); MFCD00057366; 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide; NCGC00015358-18; Isorythm; Lispine; DSSTox_CID_25536; DSSTox_RID_80938; DSSTox_GSID_45536; C21H29N3O; 4-(diisopropylamino)-2-phenyl-2-(pyridin-2-yl)butanamide; Disopyramide Free Base; 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide; 2-Pyridineacetamide, .alpha.-[2-[bis(1-methylethyl)amino]ethyl]-.alpha.-phenyl-; CAS-3737-09-5; Rythmodan P (TN); SR-01000003039; NCGC00016985-01; Prestwick_681; EINECS 223-110-2; Lispine; Ritmilen; Norpace (Salt/Mix); Spectrum_001008; Prestwick0_000266; Prestwick1_000266; Prestwick2_000266; Prestwick3_000266; Spectrum2_001033; Spectrum3_000404; Spectrum4_000524; Spectrum5_000943; D 7644; Lopac0_000402; Lopac0_000411; SCHEMBL16153; BSPBio_000112; BSPBio_001928; KBioGR_001127; KBioSS_001488; MLS002222242; DivK1c_000489; SPBio_001245; SPBio_002331; BPBio1_000124; GTPL7167; SC 13957 (Salt/Mix); DTXSID1045536; KBio1_000489; KBio2_001488; KBio2_004056; KBio2_006624; KBio3_001148; 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide; Disopyramide (JP17/USAN/INN); NINDS_000489; HMS1568F14; HMS2095F14; HMS2234G08; HMS3261A06; HMS3369O21; HMS3712F14; HMS3886E08; Disopyramide [USAN:INN:BAN:JAN]; Disopyramide 1.0 mg/ml in Methanol; Tox21_110727; Tox21_500402; 2-Pyridineacetamide, alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-; BDBM50028893; NSC791109; AKOS015894712; Tox21_110727_1; CCG-204495; DB00280; LP00402; MCULE-8866988334; NSC-791109; SDCCGSBI-0050388.P006; IDI1_000489; NCGC00015358-04; NCGC00015358-05; NCGC00015358-06; NCGC00015358-08; NCGC00015358-09; NCGC00015358-10; NCGC00015358-11; NCGC00015358-12; NCGC00015358-13; NCGC00015358-14; NCGC00015358-15; NCGC00015358-19; NCGC00015358-24; NCGC00015358-25; NCGC00093829-01; NCGC00093829-02; NCGC00093829-03; NCGC00261087-01; AC-16018; AK688967; BS-17145; HY-12533; SMR001307254; SBI-0050388.P005; AB00053462; CS-0011990; EU-0100402; FT-0667714; ST50411970; C06965; D00303; H-3292; 20509-EP2272972A1; 20509-EP2272973A1; 20509-EP2277872A1; 20509-EP2314585A1; AB00053462_16; AB00053462_17; Q425120; SR-01000003039-3; 4-Diisopropylamino-2-phenyl-2-(2-pyridyl)-butyramide; BRD-A29734509-001-03-8; BRD-A29734509-011-02-9; BRD-A29734509-011-06-0; SR-01000003039-10; 4-(Diisopropylamino)-2-phenyl-2-(2-pyridyl)butyramide; Z2786051711; 4-(Diisopropylamino)-2-phenyl-2-(2-pyridinyl)butanamide #; 4-[bis(methylethyl)amino]-2-phenyl-2-(2-pyridyl)butanamide; Disopyramide, European Pharmacopoeia (EP) Reference Standard; .alpha.-(2-(Diisopropylamino)ethyl)-.alpha.-phenyl-2-pyridineacetamide; .gamma.-Diisopropylamino-.alpha.-phenyl-.alpha.-(2-pyridyl)butyramide; 2-Pyridineacetamide, .alpha.-[2-(diisopropylamino)ethyl]-.alpha.-phenyl-; 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanimidic acid; racemic 2-phenyl-2-(2-pyridyl)-4-[N,N-bis(1-methylethyl)amino]butanamide; 1216989-88-6
Clinical Status
Approved
Disease Indication Ventricular tachyarrhythmia ICD-11: BC71 [1]
PubChem CID
3114
Formula
C21H29N3O
Canonical SMILES
CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C
InChI
1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)
InChIKey
UVTNFZQICZKOEM-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3114"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 339.5 Topological Polar Surface Area 59.2
XlogP 3.2 Complexity 409
Heavy Atom Count 25 Rotatable Bond Count 8
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Disopyramide 100 mg capsule Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Sorbitan monolaurate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Aluminum oxide; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Carilion Materials Management; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Sorbitan monolaurate DIG Info Multidrug resistance protein 1 (Inhibition ratio > 70 %) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Propylene glycol; Titanium dioxide; Silicon dioxide; Aluminum oxide; Gelatin
                   Dosage Form Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; D&c red no. 28; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Magnesium stearate; Propylparaben; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [7]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Fd&c yellow no. 6; Talc; Titanium dioxide; Fd&c red no. 3; Gelatin, unspecified; Starch, corn
                   Dosage Form Oral Capsule
                   Company G.D. Searle LLC Division of Pfizer Inc
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucrose; Talc; Titanium dioxide; Ethylcellulose, unspecified; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company G.D. Searle LLC Division of Pfizer Inc
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sucrose; Talc; Titanium dioxide; Ethylcelluloses; Starch, corn
                   Dosage Form Oral Capsule
                   Company Carilion Materials Management
          Disopyramide 150 mg capsule Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Sorbitan monolaurate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Aluminum oxide; Gelatin; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Sorbitan monolaurate DIG Info Multidrug resistance protein 1 (Inhibition ratio > 70 %) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Lactose monohydrate; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Sorbitan monolaurate; Ferrosoferric oxide; Propylene glycol; Titanium dioxide; Aluminum oxide; Gelatin, unspecified; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Oral Capsule
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Sorbitan monolaurate DIG Info Multidrug resistance protein 1 (Inhibition ratio > 70 %) [6]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Sodium lauryl sulfate; D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Magnesium stearate; Propylene glycol; Titanium dioxide; Silicon dioxide; Aluminum oxide; Gelatin
                   Dosage Form Oral Capsule
                   Company AvKARE
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Methylparaben; Sodium lauryl sulfate; Magnesium stearate; Propylparaben; Ferric oxide red; Ferrosoferric oxide; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Gelatin
                   Dosage Form Oral Capsule
                   Company Actavis Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
methylparaben DIG Info Carbonic anhydrase VII (Ki = 780 nM) [7]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Propyl 4-hydroxybenzoate DIG Info Estrogen receptor alpha (IC50 = 11 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Fd&c yellow no. 6; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Ethylcellulose, unspecified; Gelatin, unspecified; Shellac; Starch, corn
                   Dosage Form 12 HR Extended Release Oral Capsule
                   Company G.D. Searle LLC Division of Pfizer Inc
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Fd&c yellow no. 6; Sucrose; Talc; Titanium dioxide; Fd&c red no. 3; Ethylcelluloses; Gelatin; Shellac; Starch, corn
                   Dosage Form Oral Capsule
                   Company Carilion Materials Management
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose, unspecified form; Fd&c blue no. 1; Fd&c yellow no. 6; Talc; Titanium dioxide; Fd&c red no. 3; Gelatin, unspecified; Starch, corn
                   Dosage Form Oral Capsule
                   Company G.D. Searle LLC Division of Pfizer Inc
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
          Disopyramide Phosphate eq 100mg base capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose Monohydrate; Magnesium Stearate; Sodium Starch Glycolate; Black Iron Oxide; D&C Red 28; D&C Red 33; D&C Yellow 10; D&C Yellow 10 Aluminum Lake; Fd&C Blue 1; Fd&C Blue 1 Aluminum Lake; Fd&C Blue 2 Aluminum Lake; Fd&C Red 40 Aluminum Lake; Gelatin; Propylene Glycol; Shellac; Sodium Lauryl Sulfate; Sorbitan Monolaurate; Titanium Dioxide
                   Dosage Form Capsule
                   Company Teva Pharmaceuticals Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Food blue 1 aluminum lake DIG Info Leukemia MT4 cells (IC50 = 1288.25 nM) [8]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [9]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Sorbitan monolaurate DIG Info Multidrug resistance protein 1 (Inhibition ratio > 70 %) [6]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Corn Starch; D&C Yellow No 10; Edible Ink; Ethylcellulose; Fd&C Blue No 1; Gelatin; Shellac; Sucrose; Talc; Titanium Dioxide
                   Dosage Form Capsule
                   Company Pfizer Laboratories Div Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Food blue 1 aluminum lake DIG Info Leukemia MT4 cells (IC50 = 1288.25 nM) [8]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [9]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Corn Starch; Edible Ink; Fd&C Red No 3; Fd&C Yellow No 6; Gelatin; Lactose; Talc; Titanium Dioxide
                   Dosage Form Capsule
                   Company Pfizer Laboratories Div Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Erythrosine sodium anhydrous DIG Info Multidrug resistance protein 3 (IC50 = 133000 nM) [10]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [9]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [5]
          Disopyramide Phosphate eq 150mg base capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Corn Starch; D&C Yellow No 10; Edible Ink; Ethylcellulose; Fd&C Blue No 1; Gelatin; Shellac; Sucrose; Talc; Titanium Dioxide; Fd&C Red No 3; Fd&C Yellow No 6
                   Dosage Form Capsule
                   Company Pfizer Laboratories Div Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Erythrosine sodium anhydrous DIG Info Multidrug resistance protein 3 (IC50 = 133000 nM) [10]
Food blue 1 aluminum lake DIG Info Leukemia MT4 cells (IC50 = 1288.25 nM) [8]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [9]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Corn Starch; Edible Ink; Fd&C Red No 3; Fd&C Yellow No 6; Gelatin; Lactose; Talc; Titanium Dioxide; Fd&C Blue No 1
                   Dosage Form Capsule
                   Company Pfizer Laboratories Div Pfizer
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Erythrosine sodium anhydrous DIG Info Multidrug resistance protein 3 (IC50 = 133000 nM) [10]
Food blue 1 aluminum lake DIG Info Leukemia MT4 cells (IC50 = 1288.25 nM) [8]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [9]
Pregelatinized starch DIG Info Multidrug resistance protein 1 (Protein expression downregulation) [5]
References
1 FDA label for approved disopyramide from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Effect of excipients on breast cancer resistance protein substrate uptake activity. J Control Release. 2007 Dec 4;124(1-2):1-5.
7 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV. Bioorg Med Chem. 2013 Mar 15; 21(6):1564-9.
8 Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues. J Med Chem. 2006 Feb 23; 49(4):1291-312.
9 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
10 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov; 136(1):216-41.

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