Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00195)
Name
Didanosine
Synonyms    Click to Show/Hide the Synonyms of This API
2',3'-Dideoxyinosine; 69655-05-6; DIDEOXYINOSINE; Videx EC; Inosine, 2',3'-dideoxy-; Didanosina; Didanosinum; 2,3-dideoxyinosine; BMY-40900; UNII-K3GDH6OH08; NSC-612049; K3GDH6OH08; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one; CHEBI:490877; NSC 612049; MFCD00077728; 9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE; NCGC00090691-03; NCGC00159514-02; DSSTox_CID_2927; 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one; DSSTox_RID_76791; DSSTox_GSID_22927; 2',3'-Dideoxyinosine (ddI); Hypoxanthine ddN; Didanosinum [INN-Latin]; NSC612049; Didanosina [INN-Spanish]; 9-[(2R,5S)-5-(HYDROXYMETHYL)OXOLAN-2-YL]-6,9-DIHYDRO-3H-PURIN-6-ONE; SMR000058576; Videx(TM); Intron A & Videx; CAS-69655-05-6; Videx (TN); PC-SOD+ddI; Dideoxyinosine (DDI); LOA & ddI; ddI + d4T combination; ddI & GM-CSF; SR-05000001487; DRG-0016; DDI and rIFN.alpha.2; BMY 40900; ddI & sCD4(rsCD4); 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one; CCRIS 805; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purin-6-one; DS-4152 & ddI; HSDB 6548; Didanosine,(S); Didanosine [USAN:USP:INN:BAN]; Didanosine (DDI); 9-(2,3-Dideoxy-beta-D-ribofuranosyl)-6-oxopurine; Didanosine (Videx); Didanosine and Interferon-.alpha.-2; Videx EC(TM)(slow-release capsules); KS-1049; BRN 3619529; 2',3'-didesoxyinosin; 2',3'-Dideoxyinosine (AIDS Initiative); ddI & IFN-.alpha.; 2', 3'-dideoxyinosine; SCHEMBL3363; CHEMBL1460; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)hypoxanthine; Listera ovata agglutinin & 2',3'-Dideoxyinosine; Didanosine (JAN/USP/INN); MLS000759469; MLS001055350; MLS001424118; MLS002154216; MLS006011561; 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine; GTPL4833; INO001; DTXSID6022927; 2',3'-Dideoxyinosine & sCD4(soluble recombinant protein); HMS2051J11; HMS2089N20; HMS2095O08; HMS2232P22; HMS3712O08; HMS3884M06; HY-B0249; Didanosine system suitability mixture; Tox21_111732; Tox21_202333; Tox21_300575; 9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one; ANW-35738; BDBM50404252; Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxyinosine; ZINC13597823; 2',3'-Dideoxyinosine & Granulocyte-macrophage colony-stimulating factor; 2',3'-DIDEOXYINOSINE; Didanosine; AKOS015833088; AKOS015901454; AKOS015963259; AKOS026750545; Tox21_111732_1; AB02981; CCG-100947; CCG-220153; DB00900; MCULE-2844514954; NC00197; 9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one; SRI-7013-04; SRI-7013-05; SRI-7013_07; NCGC00090691-01; NCGC00090691-02; NCGC00159514-03; NCGC00159514-04; NCGC00164280-01; NCGC00188983-01; NCGC00254496-01; NCGC00259882-01; NCGC00390773-01; AC-12026; AC-32186; Didanosine 100 microg/mL in Acetonitrile; SMR004703324; 2',3'-Dideoxyinosine, >=98% (HPLC); AB0014064; AB0069772; 2',3'-Dideoxyinosine & Interferon-.alpha.; SW198619-2; 9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran; C06953; D00296; J10315; 655D056; Q422606; J-700356; SR-05000001487-1; SR-05000001487-2; W-203551; Z1692482604; Didanosine, European Pharmacopoeia (EP) Reference Standard; 9-[(2R,5S)-5-(hydroxymethyl)-2-oxolanyl]-3H-purin-6-one; Didanosine, United States Pharmacopeia (USP) Reference Standard; Inosine, 2',3'-dideoxy- & Recombinant Interferon-.alpha.-2; Lecithinized superoxide dismutase & Inosine, 2',3'-dideoxy-; 9-((2S,5R)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ol; 2 inverted exclamation mark ,3 inverted exclamation mark -Dideoxyinosine; 9-((2R,5S)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-1H-PURIN-6(9H)-ONE; 9-[(2R,5S)-5-(HYDROXYMETHYL)OXOLAN-2-YL]-6,9-DIHYDRO-1H-PURIN-6-ONE
Clinical Status
Approved
Disease Indication Human immunodeficiency virus infection ICD-11: 1C60 [1]
PubChem CID
135398739
Formula
C10H12N4O3
Canonical SMILES
C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O
InChI
1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChIKey
BXZVVICBKDXVGW-NKWVEPMBSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=135398739"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 236.23 Topological Polar Surface Area 88.7
XlogP -1.2 Complexity 348
Heavy Atom Count 17 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Didanosine 200 mg capsule Click to Show/Hide the Full List of Formulation(s):          4 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Indigotindisulfonate sodium; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Silicon dioxide; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (50 mpa.s); Hypromellose 2910 (6 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Polydextrose; Polyethylene glycol 8000; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Trisodium citrate dihydrate; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ferrosoferric oxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Sodium hydroxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Gelatin; Methacrylic acid - methyl methacrylate copolymer (1:2); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Bristol-Myers Squibb Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
          Didanosine 400 mg capsule Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Indigotindisulfonate sodium; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Silicon dioxide; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (50 mpa.s); Hypromellose 2910 (6 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Polydextrose; Polyethylene glycol 8000; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; D&c red no. 33; Fd&c blue no. 1; Fd&c blue no. 2; Fd&c yellow no. 6; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Hypromellose; Silicon dioxide; Cellulose, microcrystalline; Ferric oxide; Gelatin; Hydroxypropyl cellulose; Methacrylic acid; Polydextrose; Polyethylene glycol; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 33 DIG Info Solute carrier SLCO2B1 (Ki = 58.1 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Trisodium citrate dihydrate; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ferrosoferric oxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Sodium hydroxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Gelatin; Methacrylic acid - methyl methacrylate copolymer (1:2); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Bristol-Myers Squibb Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
          Didanosine 250 mg capsule Click to Show/Hide the Full List of Formulation(s):          6 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Indigotindisulfonate sodium; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Silicon dioxide; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose 2910 (3 mpa.s); Hypromellose 2910 (50 mpa.s); Hypromellose 2910 (6 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Microcrystalline cellulose; Polydextrose; Polyethylene glycol 8000; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Hypromellose; Silicon dioxide; Cellulose, microcrystalline; Ferric oxide; Gelatin; Hydroxypropyl cellulose; Methacrylic acid; Polydextrose; Polyethylene glycol; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [6]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Fd&c blue no. 2; Ferrosoferric oxide; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triacetin; Triethyl citrate; Croscarmellose sodium; Silicon dioxide; Aluminum oxide; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose; Hypromelloses; Methacrylic acid; Polydextrose; Polyethylene glycol; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ammonia; Ferric oxide red; Ferric oxide yellow; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Trisodium citrate dihydrate; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ferrosoferric oxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Sodium hydroxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Gelatin; Methacrylic acid - methyl methacrylate copolymer (1:2); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Bristol-Myers Squibb Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
          Didanosine 125 mg capsule Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Trisodium citrate dihydrate; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [4]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Diethyl phthalate; Ferrosoferric oxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Silicon dioxide; Gelatin; Hypromellose 2910 (3 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Diethyl phthalate; Sodium hydroxide; Talc; Titanium dioxide; Carboxymethylcellulose sodium; Gelatin; Methacrylic acid - methyl methacrylate copolymer (1:2); Sodium starch glycolate type a potato
                   Dosage Form Delayed Release Oral Capsule
                   Company Bristol-Myers Squibb Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Diethyl phthalate DIG Info Phosphodiesterase 4D (IC50 = 8.5 uM) [2]
Carboxymethylcellulose sodium DIG Info Albendazole monooxygenase (EC50 = 12.6 uM) [6]
          Didanosine 100 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; Magnesium stearate; Sorbitol; Magnesium hydroxide; Crospovidone; Cellulose, microcrystalline; Orange
                   Dosage Form Chewable Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [7]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Didanosine 150 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; Magnesium stearate; Sorbitol; Magnesium hydroxide; Crospovidone; Cellulose, microcrystalline; Orange
                   Dosage Form Chewable Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [7]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
          Didanosine 200 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Aspartame; Magnesium stearate; Sorbitol; Magnesium hydroxide; Crospovidone; Cellulose, microcrystalline; Orange
                   Dosage Form Chewable Tablet
                   Company Aurobindo Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [7]
Aspartame DIG Info Pregnane X receptor (Ki = 13 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [5]
References
1 FDA label for approved didanosine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
5 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
6 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
7 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.

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