Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00267)
Name
Felodipine
Synonyms    Click to Show/Hide the Synonyms of This API
felodipine; 72509-76-3; Plendil; Flodil; Renedil; Feloday; Munobal; Splendil; dl-Felodipine; Perfudal; Prevex; Felodipina; Felodipinum; Felodipinum [INN-Latin]; Felodipina [INN-Spanish]; C18H19Cl2NO4; 86189-69-7; Felodipine (Plendil); H 154/82; Plendil ER; Felogard; MFCD00868316; Penedil; Preslow; Munobal Retard; Plendil Retard; H-154/82; Plendil Depottab; MLS000069629; CHEBI:585948; Felodur ER; AGON SR; NCGC00015455-03; Plandil; SMR000058204; DSSTox_CID_3042; DSSTox_RID_76848; DSSTox_GSID_23042; Felodipine [USAN:BAN:INN]; Logimax; Plendil (TN); CGH-869; SR-01000075890; BRN 4331472; Perfuda; Plendil;Renedil; Felodipine, solid; C08CA02; Felodipine,(S); Felodipine [USAN:USP:INN:BAN]; 3,5-dicarboxylate; Prestwick_797; CAS-72509-76-3; Felodipine (dl form); PubChem15919; Opera_ID_1873; Prestwick0_000478; Prestwick1_000478; Prestwick2_000478; Prestwick3_000478; (.+/-.)-Felodipine; F 9677; CHEMBL1480; Lopac0_000508; SCHEMBL26398; BSPBio_000616; AE-641/11429675; MLS001077361; MLS001333735; MLS002153409; MLS002153832; MLS003876820; BIDD:GT0733; SPBio_002555; BPBio1_000678; Felodipine (JP17/USP/INN); GTPL4190; CHEMBL3196476; DTXSID4023042; SCHEMBL13460298; BDBM189379; HMS1569O18; HMS2089J05; HMS2096O18; HMS2232D24; HMS3259F12; HMS3261F17; HMS3651O21; HMS3713O18; HMS3884I14; Pharmakon1600-01505887; BCP02192; BCP22685; HY-B0309; 2,6-dimethyl-1,4-dihydropyridine-; Tox21_110155; Tox21_500508; ANW-42236; CA-236; NSC760343; AKOS015891545; Tox21_110155_1; AC-2124; BCP9000680; CCG-204599; DB01023; KS-1264; LP00508; MCULE-8253440089; NC00721; NSC-760343; SDCCGSBI-0050492.P002; NCGC00015455-04; NCGC00015455-05; NCGC00015455-06; NCGC00015455-07; NCGC00015455-08; NCGC00015455-10; NCGC00015455-24; NCGC00024087-02; NCGC00093906-01; NCGC00093906-02; NCGC00261193-01; AC-24403; AK543880; SMR002529504; SY053174; AB0014113; 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-; EU-0100508; FT-0626393; FT-0660933; FT-0668475; SW219299-1; EN300-70726; D00319; S-8162; 509F763; Q420644; SR-01000075890-1; SR-01000075890-4; BRD-A30815329-001-03-0; Z239864852; Felodipine, European Pharmacopoeia (EP) Reference Standard; Felodipine, United States Pharmacopeia (USP) Reference Standard
Clinical Status
Approved
Disease Indication Essential hypertension ICD-11: BA00 [1]
PubChem CID
3333
Formula
C18H19Cl2NO4
Canonical SMILES
CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
InChI
1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3333"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 384.2 Topological Polar Surface Area 64.599
XlogP 3.9 Complexity 614
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Full List of Drug Formulations (DFMs) Containing This API
          Felodipine 10 mg tablet Click to Show/Hide the Full List of Formulation(s):        17 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Fd&c red no. 40; Sodium stearyl fumarate; Fd&c blue no. 2; Propyl gallate; Titanium dioxide; Sodium aluminium silicate; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (15000 mpa.s); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Jubilant Cadista Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Sodium stearyl fumarate; Fd&c blue no. 2; Fd&c yellow no. 6; Butylated hydroxyanisole; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 2; Titanium dioxide; Hypromellose; Povidone; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Polyethylene glycol; Starch, corn
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [9]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Polyethylene glycol 6000; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (50 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Sodium stearyl fumarate; Fd&c yellow no. 6; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Wockhardt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 2; Titanium dioxide; Povidone; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycol; Starch, corn
                   Dosage Form 24 HR Extended Release Tablet
                   Company PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 2; Titanium dioxide; Silicon dioxide; Aluminum oxide; Carnauba wax; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 2; Titanium dioxide; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 2; Titanium dioxide; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycols; Povidone k29/32
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Povidone; Alcohol; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Magnesium aluminum silicate; Titanium dioxide; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (5 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [6]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Propyl gallate; Calcium silicate; Ferric oxide red; Titanium dioxide; Triacetin; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Peg-40 castor oil
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Alcohol; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Ferric oxide red; Ferric oxide yellow; Kaolin; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company A-S Medication Solutions; Glenmark Pharmaceutials; Medsource Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Titanium dioxide; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Ranbaxy Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
          Felodipine 5 mg tablet Click to Show/Hide the Full List of Formulation(s):        16 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; D&c yellow no. 10; Sodium stearyl fumarate; Fd&c blue no. 2; Fd&c yellow no. 6; Butylated hydroxyanisole; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals; NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Titanium dioxide; Hypromellose; Polysorbate 80; Povidone; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Polyethylene glycol; Starch, corn
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [9]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Polyethylene glycol 6000; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (50 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide yellow; Titanium dioxide; Sodium aluminium silicate; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (15000 mpa.s); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Jubilant Cadista Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Sodium stearyl fumarate; Fd&c yellow no. 6; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Wockhardt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Titanium dioxide; Polysorbate 80; Povidone; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycol; Starch, corn
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Medsource Pharmaceuticals; Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Titanium dioxide; Polysorbate 80; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE; PD-Rx Pharmaceuticals; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Titanium dioxide; Polysorbate 80; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Titanium dioxide; Polysorbate 80; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols; Povidone k29/32
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Povidone; Alcohol; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Ferric oxide yellow; Magnesium aluminum silicate; Titanium dioxide; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (5 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [6]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Propyl gallate; Calcium silicate; Ferric oxide red; Titanium dioxide; Triacetin; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Peg-40 castor oil
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Propyl gallate; Calcium silicate; Ferric oxide red; Titanium dioxide; Triacetin; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Peg-40 castor oil
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Ferric oxide red; Ferric oxide yellow; Kaolin; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Carilion Materials Management; Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Titanium dioxide; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Ranbaxy Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
          Felodipine 2.5 mg tablet Click to Show/Hide the Full List of Formulation(s):        14 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Fd&c blue no. 2; Propyl gallate; Ferric oxide yellow; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Fd&c blue no. 2; Propyl gallate; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Polyethylene glycol 6000; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromellose 2208 (100 mpa.s); Hypromellose 2910 (50 mpa.s); Hypromellose 2910 (6 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Aurobindo Pharma; Citron Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 6000 DIG Info Albendazole monooxygenase (Inhibition ratio < 70 %) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Titanium dioxide; Hypromellose; Povidone; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Polyethylene glycol; Starch, corn
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [9]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Fd&c blue no. 2; Propyl gallate; Ferric oxide yellow; Magnesium oxide; Propylene glycol; Talc; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Cellulose, microcrystalline; Colloidal silicon dioxide; Hydroxypropyl cellulose; Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [6]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Propyl gallate; Titanium dioxide; Sodium aluminium silicate; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromellose 2910 (15000 mpa.s); Hypromelloses
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Jubilant Cadista Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [6]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Sodium stearyl fumarate; Fd&c blue no. 2; Ferric oxide yellow; Kaolin; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Glenmark Pharmaceutials
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; D&c yellow no. 10; Sodium stearyl fumarate; Ferric oxide yellow; Magnesium aluminum silicate; Titanium dioxide; Polyethylene glycol 400; Polyoxyl 40 hydrogenated castor oil; Hydroxypropyl cellulose; Hypromellose 2208 (15000 mpa.s); Hypromellose 2910 (5 mpa.s)
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Heritage Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Polyethylene glycol 400 DIG Info Albendazole monooxygenase (IC50 = 10.77 mg.mL-1) [6]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Titanium dioxide; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AvKARE; Carilion Materials Management; Sun Pharmaceutical Industries
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c yellow no. 10; Fd&c red no. 40; Fd&c blue no. 1; Titanium dioxide; Silicon dioxide; Aluminum oxide; Carnauba wax; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycols; Povidone k29/32
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butylated hydroxytoluene; Sodium stearyl fumarate; Butylated hydroxyanisole; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polydextrose; Polyethylene glycols; Povidones
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Butylated hydroxytoluene DIG Info Carbonic anhydrase II (Ki = 630 nM) [8]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Butylhydroxyanisole DIG Info Prostaglandin G/H synthase 2 (IC50 = 2.6 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Fd&c blue no. 2; Propyl gallate; Calcium silicate; Ferric oxide yellow; Titanium dioxide; Triacetin; Cellulose, microcrystalline; Hydroxypropyl cellulose (type h); Hypromelloses; Peg-40 castor oil
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Sodium stearyl fumarate; Propyl gallate; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Aluminum silicate; Povidone; Alcohol; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Propyl gallate DIG Info Arachidonate 5-lipoxygenase (Ki = 0.43 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [9]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Sodium stearyl fumarate; Titanium dioxide; Polyoxyl 40 hydrogenated castor oil; Silicon dioxide; Cellulose, microcrystalline; Hydroxypropyl cellulose; Hypromelloses; Polyethylene glycol
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Wockhardt
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
Hydrogenated polyoxyl 40 castor oil DIG Info Cytochrome P450 2C9 (IC50 = 30 uM) [5]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [7]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Sodium stearyl fumarate; Fd&c blue no. 2; Ferric oxide yellow; Titanium dioxide; Hydroxypropyl cellulose
                   Dosage Form 24 HR Extended Release Oral Tablet
                   Company Ranbaxy Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [4]
References
1 FDA label for approved felodipine from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
5 Effects of non-ionic surfactants on cytochrome P450-mediated metabolism in vitro. Eur J Pharm Biopharm. 2011 May;78(1):166-72.
6 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
7 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
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