Details of the Drug Formulation (DFM)
General Information of DFM (ID: F15206) | |||||
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Name |
Nicotinic acid 1000 mg tablet
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Company |
Lannett Company
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Active Pharmaceutical Ingredient (API) | Nicotinic acid | API Info click to show the detail info of this API | |||
Lung cancer | ICD-11: 2C25 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E09YYN | DIG Info | Eisenoxyd | Colorant | ||
E0M0IE | DIG Info | Ferric hydroxide oxide yellow | Colorant | ||
E0D4QT | DIG Info | Polyethylene glycol 1000 | Coating agent ... | ||
E01UTV | DIG Info | Silicon dioxide | Anticaking agent ... | ||
E0RS6F | DIG Info | Sodium stearyl fumarate | lubricant | ||
E0HR5F | DIG Info | Soybean lecithin | Other agent | ||
E0QY1F | DIG Info | Talc | Anticaking agent ... | ||
E05BSD | DIG Info | Titanium dioxide | Coating agent ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Soybean lecithin | |||||
Biological Activity | IC50 = 6.61 mg.mL-1 (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 1000 | |||||
Biological Activity | Inhibition ratio < 60 % (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Silicon dioxide | |||||
Biological Activity | Protein expression downregulation (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
DBT Name: Cytochrome P450 2E1 (CYP2E1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 1000 | |||||
Biological Activity | IC50 = 75.3 uM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2E1_HUMAN | |||||
DBT Name: Cytochrome P450 2C9 (CYP2C9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 1000 | |||||
Biological Activity | IC50 = 365.6 uM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2C9_HUMAN | |||||
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 1000 | |||||
Biological Activity | IC50 = 139 uM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2CJ_HUMAN | |||||
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 1000 | |||||
Biological Activity | IC50 = 409.6 uM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2D6_HUMAN | |||||
DBT Name: Cytochrome P450 3A5 (CYP3A5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyethylene glycol 1000 | |||||
Biological Activity | IC50 = 78 uM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A5_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Leukemia K562 cells (K562) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium stearyl fumarate | |||||
Biological Activity | IC50 = 20.2 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.75 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0004 | |||||
DBT Name: Breast cancer MCF7 cells (MCF7) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium stearyl fumarate | |||||
Biological Activity | IC50 = 60 ug.mL-1 (estimated based on the structural similarity with CHEMBL3126829 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.75 | |||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0031 | |||||
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