Details of the Drug Formulation (DFM)
General Information of DFM (ID: F23470) | |||||
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Name |
Labetalol Hydrochloride 5mg/ml injectable
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Company |
Sebela Ireland Ltd
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Active Pharmaceutical Ingredient (API) | Labetalol | API Info click to show the detail info of this API | |||
Essential hypertension | ICD-11: BA00 | Approved | |||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0BS9U | DIG Info | Dextrose anhydrous | Binding agent ... | ||
E0FY2S | DIG Info | Edetate disodium | Complexing agent | ||
E0F6AN | DIG Info | Kyselina citronova | Acidulant ... | ||
E0V6QI | DIG Info | methylparaben | Antimicrobial preservative | ||
E0X6QO | DIG Info | Propylparaben sodium | Antimicrobial preservative | ||
E0L2PN | DIG Info | Sodium hydroxide | Alkalizing agent | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: N1-methyl adenine demethylase (FTO) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 300000 nM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | FTO_HUMAN | |||||
DBT Name: RNA demethylase ALKBH5 (ALKB5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 488000 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ALKB5_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Carbonic anhydrase I (CA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 2600 nM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH1_HUMAN | |||||
DBT Name: Carbonic anhydrase II (CA2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 3400 nM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH2_HUMAN | |||||
DBT Name: Carbonic anhydrase IX (CA9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 5500 nM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH9_HUMAN | |||||
DBT Name: Carbonic anhydrase VII (CA7) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 780 nM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH7_HUMAN | |||||
DBT Name: Carbonic anhydrase XII (CA12) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 820 nM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH12_HUMAN | |||||
DBT Name: Carbonic anhydrase XIV (CA14) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 4100 nM (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH14_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Androgen receptor (AR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 426579.52 nM (tested by experiment) | [4] | ||||
Tested Species | Rattus norvegicus (Rat) | |||||
UniProt ID | ANDR_RAT | |||||
DBT Name: Estrogen receptor alpha (ESR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylparaben sodium | |||||
Biological Activity | EC50 = 38200 nM (estimated based on the structural similarity with CHEMBL15841 ) | [5] | ||||
Structural Similarity | Tanimoto coefficient = 0.946428571 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
DBT Name: Factor HNF-4-alpha (HNF4A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 39869 nM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | HNF4A_HUMAN | |||||
Other protein families (OPF) | ||||||
DBT Name: Perilipin-1 (PLIN1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 3708 nM (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PLIN1_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lung cancer A-549 cells (A-549) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0023 | |||||
DBT Name: Hepatoblastoma HepG2 cells (HepG2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DBT Name: Cervical cancer KB cells (KB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 200000 nM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0372 | |||||
DBT Name: Carcinoma MDA-MB-231 cells (MDA-MB-231) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0062 | |||||
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