Details of the Drug Formulation (DFM)
General Information of DFM (ID: F23747) | |||||
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Name |
Fluocinolone Acetonide 0.01% ointment
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Company |
Cosette Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Fluocinolone acetonide | API Info click to show the detail info of this API | |||
Approved | |||||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E07AGB | DIG Info | Cetyl alcohol | Coating agent ... | ||
E0C3HB | DIG Info | Isopropyl palmitate | Emollient ... | ||
E0V6QI | DIG Info | methylparaben | Antimicrobial preservative | ||
E0XE3V | DIG Info | Polyoxyl 40 stearate | Emulsifying agent ... | ||
E0CP7I | DIG Info | Polysorbate 60 | Dispersing agent ... | ||
E0M1JK | DIG Info | Propylene glycol | Antimicrobial preservative ... | ||
E07WRC | DIG Info | Propylene glycol monostearate | Emollient ... | ||
E0X6QO | DIG Info | Propylparaben sodium | Antimicrobial preservative | ||
E0SA9J | DIG Info | Sorbic acid | Antimicrobial preservative | ||
E0E1QN | DIG Info | Sorbitan monostearate | Dispersing agent ... | ||
E0H2SC | DIG Info | Water | Solvent | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Coumarin 7-hydroxylase (CYP2A6) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 950.1 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2A6_HUMAN | |||||
DBT Name: Cytochrome P450 3A (CYP3A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 6800 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN ; CP3A5_HUMAN ; CP3A7_HUMAN ; CP343_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylene glycol | |||||
Biological Activity | Inhibition ratio < 20 % (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 322.2 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
DBT Name: Cytochrome P450 2C9 (CYP2C9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 27.4 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2C9_HUMAN | |||||
DBT Name: Mephenytoin 4-hydroxylase (CYP2C19) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 20.6 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2CJ_HUMAN | |||||
DBT Name: Debrisoquine 4-hydroxylase (CYP2D6) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 491.7 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP2D6_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Acylsphingosine deacylase NAAA (ASAHL) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Isopropyl palmitate | |||||
Biological Activity | IC50 = 19000 nM (estimated based on the structural similarity with CHEMBL139056 ) | [4] | ||||
Structural Similarity | Tanimoto coefficient = 0.954545455 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | NAAA_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Carbonic anhydrase I (CA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 2600 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH1_HUMAN | |||||
DBT Name: Carbonic anhydrase II (CA2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 3400 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH2_HUMAN | |||||
DBT Name: Carbonic anhydrase IX (CA9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 5500 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH9_HUMAN | |||||
DBT Name: Carbonic anhydrase VII (CA7) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 780 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH7_HUMAN | |||||
DBT Name: Carbonic anhydrase XII (CA12) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 820 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH12_HUMAN | |||||
DBT Name: Carbonic anhydrase XIV (CA14) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 4100 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH14_HUMAN | |||||
DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | IC50 = 181.3 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Primary active transporter (PAT) | ||||||
DBT Name: Multidrug resistance protein 1 (ABCB1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylene glycol monostearate | |||||
Biological Activity | Inhibition ratio = 25 % (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Polyoxyl 40 stearate | |||||
Biological Activity | Inhibition ratio = 72.1 % (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | MDR1_HUMAN ; MDR3_HUMAN ; ABCB5_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Androgen receptor (AR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 426579.52 nM (tested by experiment) | [7] | ||||
Tested Species | Rattus norvegicus (Rat) | |||||
UniProt ID | ANDR_RAT | |||||
DBT Name: Estrogen receptor alpha (ESR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylparaben sodium | |||||
Biological Activity | EC50 = 38200 nM (estimated based on the structural similarity with CHEMBL15841 ) | [8] | ||||
Structural Similarity | Tanimoto coefficient = 0.946428571 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lung cancer A-549 cells (A-549) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0023 | |||||
DBT Name: Breast cancer FM3A cells (FM3A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Cetyl alcohol | |||||
Biological Activity | EC50 = 1600 nM (estimated based on the structural similarity with CHEMBL28459 ) | [10] | ||||
Structural Similarity | Tanimoto coefficient = 0.861111111 | |||||
Tested Species | Mus musculus (Mouse) | |||||
Cellosaurus ID | CVCL_3869 | |||||
DBT Name: Hepatoblastoma HepG2 cells (HepG2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DBT Name: Cervical cancer KB cells (KB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 200000 nM (tested by experiment) | [11] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0372 | |||||
DBT Name: Carcinoma MDA-MB-231 cells (MDA-MB-231) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0062 | |||||
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