Details of the Drug Formulation (DFM)
General Information of DFM (ID: F24383) | |||||
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Name |
Procaine 300000 units/ml injectable
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Company |
King Pharmaceuticals
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Active Pharmaceutical Ingredient (API) | Procaine | API Info click to show the detail info of this API | |||
Approved | |||||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E07TDY | DIG Info | Carboxymethylcellulose | Adsorbent ... | ||
E0V6QI | DIG Info | methylparaben | Antimicrobial preservative | ||
E0Q7IF | DIG Info | Povidone | Binding agent ... | ||
E0X6QO | DIG Info | Propylparaben sodium | Antimicrobial preservative | ||
E0M5SQ | DIG Info | Sodium citrate anhydrous | Alkalizing agent ... | ||
E0HR5F | DIG Info | Soybean lecithin | Other agent | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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Oxidoreductase (ORase) | ||||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Soybean lecithin | |||||
Biological Activity | IC50 = 6.61 mg.mL-1 (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | IC50 = 107 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Experiment (3) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | Protein expression upregulation (tested by experiment) | [3] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Lyase/isomerase/ligase (L/I/G) | ||||||
DBT Name: Carbonic anhydrase I (CA1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 2600 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH1_HUMAN | |||||
DBT Name: Carbonic anhydrase II (CA2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 3400 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH2_HUMAN | |||||
DBT Name: Carbonic anhydrase IV (CA4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Sodium citrate anhydrous | |||||
Biological Activity | Ki = 99 nM (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH4_HUMAN | |||||
DBT Name: Carbonic anhydrase IX (CA9) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 5500 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH9_HUMAN | |||||
DBT Name: Carbonic anhydrase VII (CA7) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 780 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH7_HUMAN | |||||
DBT Name: Carbonic anhydrase XII (CA12) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 820 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH12_HUMAN | |||||
DBT Name: Carbonic anhydrase XIV (CA14) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | Ki = 4100 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CAH14_HUMAN | |||||
DBT Name: Cholesterol 25-hydroxylase (CYP1A2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Povidone | |||||
Biological Activity | IC50 = 78.3 uM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP1A2_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Androgen receptor (AR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 426579.52 nM (tested by experiment) | [6] | ||||
Tested Species | Rattus norvegicus (Rat) | |||||
UniProt ID | ANDR_RAT | |||||
DBT Name: Estrogen receptor alpha (ESR1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylparaben sodium | |||||
Biological Activity | EC50 = 38200 nM (estimated based on the structural similarity with CHEMBL15841 ) | [7] | ||||
Structural Similarity | Tanimoto coefficient = 0.946428571 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ESR1_HUMAN | |||||
Cell line (CELL) | ||||||
DBT Name: Lung cancer A-549 cells (A-549) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0023 | |||||
DBT Name: Hepatoblastoma HepG2 cells (HepG2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0027 | |||||
DBT Name: Cervical cancer KB cells (KB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 200000 nM (tested by experiment) | [9] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0372 | |||||
DBT Name: Carcinoma MDA-MB-231 cells (MDA-MB-231) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | methylparaben | |||||
Biological Activity | IC50 > 20 ug.mL-1 (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
Cellosaurus ID | CVCL_0062 | |||||
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