Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00244)
Name
Esomeprazole
Synonyms    Click to Show/Hide the Synonyms of This API
Esomeprazole; (S)-Omeprazole; (-)-Omeprazole; 119141-88-7; (S)-(-)-Omeprazole; Nexium; Alenia; Esofag; Omeprazole S-form; Esomeprazole Sodium; UNII-N3PA6559FT; Nexiam; (S)-Esomeprazole; Esomperazole; (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole; N3PA6559FT; CHEBI:50275; esomeprazol; 1H-Benzimidazole, 5-methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-; esomeprazolum; Inexium paranova; Esomeprazole [INN:BAN]; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole; Esomeprazole (INN); Inexium paranova (TN); IZRA 40; HSDB 8158; A02BC05; r-(+)-omeprazole; 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole; SCHEMBL19535; BIDD:GT0020; GTPL5488; CHEMBL1201320; DTXSID4044292; QCR-180; ZINC4693575; ANW-57719; CE0111; AKOS015900821; AKOS016001455; AM84543; DB00736; 5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole; D07917; Q553223; BRD-K61443506-001-01-0; UNII-KG60484QX9 component SUBDBMMJDZJVOS-DEOSSOPVSA-N; (5)6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole; (5)6-methoxy-2-[[(4-methoxy-3,5dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole; (5)6-methoxy-2-[[(4methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole; (5)6-methoxy-2[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole; (5)6-methoxy-2[[(4methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole; (5)6-methoxy-2[[(4methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]1H-benzimidazole; (S)-5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole; (s)-5-methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-ylmethane-sulfinyl)-1h-benzimidazole; (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl) methylsulfinyl]1-H-benzimidazole; (S)-5-Methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylsulfinyl]-1H-benzimidazole; (s)-5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-3h-benzimidazole; (s)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole; (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; 6-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1H-1,3-benzodiazole; 6-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole; (+)-(5)6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; 326602-80-6; 5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methane]sulfinyl]-1H-1,3-benzodiazole
Clinical Status
Approved
Disease Indication Duodenal ulcer ICD-11: DA63 [1]
PubChem CID
9568614
Formula
C17H19N3O3S
Canonical SMILES
CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C(N2)C=C(C=C3)OC
InChI
1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m0/s1
InChIKey
SUBDBMMJDZJVOS-DEOSSOPVSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=9568614"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 345.4 Topological Polar Surface Area 96.3
XlogP 2.2 Complexity 453
Heavy Atom Count 24 Rotatable Bond Count 5
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Esomeprazole 20 mg capsule Click to Show/Hide the Full List of Formulation(s):        26 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Sodium lauryl sulfate; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Meglumine; Ammonia; Ferric oxide yellow; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Poloxamer 188; Silicon dioxide; Alcohol; Beet; Gelatin; Hypromellose 2910 (5 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Methyl alcohol; Methylene chloride; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Ascend Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous citric acid; D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Anhydrous dextrose; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Potassium sorbate; Ferric oxide yellow; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Gelatin hydrolysate (porcine skin, mw 3000); Polysorbate 80; Alcohol, x-ray exposed (1000 rad); Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Polyethylene glycols; Povidones; Water buffalo, cooked
                   Dosage Form Delayed Release Oral Capsule
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Kyselina citronova DIG Info Perilipin-1 (IC50 = 3708 nM) [10]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Gelatin DIG Info Mephenytoin 4-hydroxylase (EC50 = 20.5 uM) [8]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Hypromellose; Polysorbate 80; Povidone; Alcohol; Gelatin; Hydroxypropyl cellulose; Methacrylic acid; Polyethylene glycol
                   Dosage Form Delayed Release Oral Capsule
                   Company Stat Rx USA
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [8]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Hypromellose; Polysorbate 80; Povidone; Alcohol; Gelatin; Hydroxypropyl cellulose; Methacrylic acid; Polyethylene glycol
                   Dosage Form Delayed Release Oral Capsule
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [8]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Alcohol; Gelatin; Hydroxypropyl cellulose; Hypromelloses; Methacrylic acid; Polyethylene glycol
                   Dosage Form Delayed Release Oral Capsule
                   Company Physicians Total Care; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Polyethylene glycols; Povidones
                   Dosage Form Delayed Release Oral Capsule
                   Company AstraZeneca; Avera McKennan Hospital; Cardinal Health; Lake Eire Medical & Surgical Supply DBA Quality Care Products
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose; Hypromelloses; Methacrylic acid; Polyethylene glycols; Povidones
                   Dosage Form Delayed Release Oral Capsule
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Glyceryl monostearate; Magnesium stearate; Anhydrous dibasic calcium phosphate; Ferric oxide red; Ferrosoferric oxide; Magnesium oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Gelatin; Methacrylic acid - methyl methacrylate copolymer (1:2); Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Bi-Mart
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
Calcium hydrogenphosphate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Meglumine; Ammonia; Ferric oxide yellow; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Poloxamer 188; Alcohol; Gelatin; Hypromelloses; Methacrylic acid; Methyl alcohol; Methylene chloride; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [8]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Isopropyl alcohol; Magnesium stearate; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Diglycerin; Polysorbate 80; Alcohol; Gelatin; Glyceryl citrate; Hydroxide ion; Hypromellose 2208 (100 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Sugarcane
                   Dosage Form Delayed Release Oral Capsule
                   Company Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Carminic acid; Fd&c red no. 40; Fd&c blue no. 2; Glyceryl monostearate; Magnesium stearate; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Fd&c red no. 3; Polysorbate 80; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Wyeth Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Carminic acid DIG Info Protein-tyrosine phosphatase 1B (IC50 = 15000 nM) [11]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 1; Glyceryl monostearate; Magnesium stearate; Meglumine; Ferric oxide red; Talc; Titanium dioxide; Triethyl citrate; Fd&c red no. 3; Polysorbate 80; Gelatin; Hypromelloses; Polyethylene glycols; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company American Sales Company; Amerisource Bergen; BJWC; CVS Pharmacy; Cardinal Health; Costco Wholesale; DZA Brands; Dolgencorp; Family Dollar; H E B; Kmart Corporation; Kroger Company; L. Perrigo Company; McKesson; Meijer; Publix Super Markets; Rite Aid; Rugby Laboratories; Safeway; Shopko; SuperValu; Target Corporation; Topco Associates; Wakefern Food Corporation; Wal-Mart Stores; Walgreens Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Fd&c blue no. 1; Glyceryl monostearate; Ammonia; Ferric oxide yellow; Magnesium carbonate; Magnesium oxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Dextrose; Gelatin, unspecified; Hydroxypropyl cellulose, unspecified; Hypromellose, unspecified; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurohealth; Chain Drug Consortium; Discount Drug Mart; Family Dollar; Harris Teeter; Sam's West; Wal-Mart Stores
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Polyethylene glycols; Povidones
                   Dosage Form Delayed Release Oral Capsule
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Fd&c red no. 40; Fd&c blue no. 1; Glyceryl monostearate; Magnesium stearate; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid - methyl methacrylate copolymer (1:1); Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Wyeth Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Fd&c red no. 40; Fd&c blue no. 1; Glyceryl monostearate; Magnesium stearate; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid - methyl methacrylate copolymer (1:1); Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Butyl alcohol; Isopropyl alcohol; Ammonia; Ferric oxide yellow; Magnesium carbonate; Magnesium oxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Alcohol; Dextrose; Gelatin; Glyceryl cocoate; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurobindo Pharma; NorthStar Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 22 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl monostearate; Magnesium stearate; Magnesium oxide; Potassium hydroxide; Propylene glycol; Sodium hydroxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Ethylcelluloses; Gelatin; Glyceryl stearate se; Methacrylic acid; Povidone k90; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 23 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl monostearate; Magnesium stearate; Magnesium oxide; Potassium hydroxide; Propylene glycol; Sodium hydroxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Ethylcellulose, unspecified; Gelatin, unspecified; Glyceryl stearate se; Methacrylic acid; Povidone k90; Povidone, unspecified; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 24 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Ferric oxide yellow; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hypromellose 2910 (15 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company PureTek Corporation; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 25 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Crospovidone (15 mpa.s at 5%); Gelatin; Hydroxypropyl cellulose (type h); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [16]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
             Drug Formulation 26 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Crospovidone (15 mpa.s at 5%); Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [16]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
          Esomeprazole 40 mg capsule Click to Show/Hide the Full List of Formulation(s):        19 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Sodium lauryl sulfate; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Meglumine; Ammonia; Ferric oxide yellow; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Poloxamer 188; Silicon dioxide; Alcohol; Beet; Gelatin; Hypromellose 2910 (5 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Methyl alcohol; Methylene chloride; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Ascend Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Hypromellose; Polysorbate 80; Povidone; Alcohol; Gelatin; Hydroxypropyl cellulose; Methacrylic acid; Polyethylene glycol
                   Dosage Form Delayed Release Oral Capsule
                   Company A-S Medication Solutions
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Hypromellose DIG Info Cytochrome P450 3A5 (IC50 = 19.4 uM) [8]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Alcohol; Gelatin; Hydroxypropyl cellulose; Hypromelloses; Methacrylic acid; Polyethylene glycol
                   Dosage Form Delayed Release Oral Capsule
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; Physicians Total Care; Rebel Distributors
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid; Polyethylene glycol, unspecified; Povidone, unspecified
                   Dosage Form Delayed Release Oral Capsule
                   Company A-S Medication Solutions; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Polyethylene glycols; Povidones
                   Dosage Form Delayed Release Oral Capsule
                   Company AstraZeneca; Avera McKennan Hospital; Cardinal Health; Clinical Solutions Wholesale; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; D&c yellow no. 10; Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose; Hypromelloses; Methacrylic acid; Polyethylene glycols; Povidones
                   Dosage Form Delayed Release Oral Capsule
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Quinoline yellow WS DIG Info Estrogen receptor alpha (IC50 = 18 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Meglumine; Ammonia; Ferric oxide yellow; Propylene glycol; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Poloxamer 188; Alcohol; Gelatin; Hypromelloses; Methacrylic acid; Methyl alcohol; Methylene chloride; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Camber Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Meglumine DIG Info Alglucerase (IC50 = 447000 nM) [4]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Poloxamer 188 DIG Info Albendazole monooxygenase (IC50 = 60 uM) [8]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
D&c red no. 28; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company DirectRX; Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
D&C red no. 28 DIG Info Organic anion transporter 1 (Ki = 0.064 uM) [2]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Butyl alcohol; Fd&c blue no. 1; Isopropyl alcohol; Magnesium stearate; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Diglycerin; Fd&c red no. 3; Polysorbate 80; Alcohol; Gelatin; Glyceryl citrate; Hydroxide ion; Hypromellose 2208 (100 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Sugarcane
                   Dosage Form Delayed Release Oral Capsule
                   Company Lannett Company
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
FD&C red no. 3 DIG Info Phosphodiesterase 3A (IC50 = 0.092 uM) [2]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company American Health Packaging
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Bryant Ranch Prepack; Major Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Dr Reddy's Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Butyl alcohol; Fd&c blue no. 1; Glyceryl monostearate; Isopropyl alcohol; Magnesium stearate; Sodium hydroxide; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Alcohol; Gelatin; Hydroxypropyl cellulose (type h); Hypromelloses; Methacrylic acid; Polyethylene glycols; Povidones
                   Dosage Form Delayed Release Oral Capsule
                   Company AstraZeneca
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium lauryl sulfate; Butyl alcohol; Isopropyl alcohol; Ammonia; Ferric oxide yellow; Magnesium carbonate; Magnesium oxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Silicon dioxide; Alcohol; Dextrose; Gelatin; Glyceryl cocoate; Hydroxypropyl cellulose (type h); Hypromellose 2910 (3 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Aurobindo Pharma; NorthStar Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Isopropyl alcohol DIG Info Lymphoma P388/ADR cells (IC50 = 0.22 uM) [5]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl monostearate; Magnesium stearate; Magnesium oxide; Potassium hydroxide; Propylene glycol; Sodium hydroxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Povidone; Ethylcelluloses; Gelatin; Glyceryl stearate se; Methacrylic acid; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidone k90; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Lake Eire Medical & Surgical Supply DBA Quality Care Products; NuCare Pharmaceuticals; RemedyRepack; Torrent Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [8]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Glyceryl monostearate; Magnesium stearate; Magnesium oxide; Potassium hydroxide; Propylene glycol; Sodium hydroxide; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Ethylcelluloses; Gelatin; Glyceryl stearate se; Methacrylic acid; Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Povidone k90; Povidones; Shellac
                   Dosage Form Delayed Release Oral Capsule
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c blue no. 1; Ferric oxide yellow; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hypromellose 2910 (15 mpa.s); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company DirectRX; Teva Pharmaceuticals; Unit Dose Services
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Crospovidone (15 mpa.s at 5%); Gelatin; Hydroxypropyl cellulose (type h); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [16]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Mannitol; Ammonia; Ferrosoferric oxide; Potassium hydroxide; Propylene glycol; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Crospovidone (15 mpa.s at 5%); Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Methacrylic acid - ethyl acrylate copolymer (1:1) type a; Shellac; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [16]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
          Esomeprazole 20 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Fd&c red no. 40; Sodium stearyl fumarate; D&c red no. 27; Fd&c blue no. 2; Glyceryl monostearate; Magnesium stearate; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Crospovidone (15 mpa.s at 5%); Hydroxypropyl cellulose (1200000 mw); Hypromellose, unspecified; Methacrylic acid - methyl methacrylate copolymer (1:1); Mica; Microcrystalline cellulose; Paraffin; Polyethylene glycol, unspecified; Starch, corn
                   Dosage Form Delayed Release Oral Tablet
                   Company Pfizer Consumer Healthcare
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
D&C red no. 27 DIG Info Solute carrier SLCO2B1 (Ki = 1 uM) [3]
FD&C blue no. 2 DIG Info Adenosine receptor A3 (IC50 = 1 uM) [2]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [12]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [9]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium stearate; Lactose monohydrate; Sodium lauryl sulfate; Sodium stearyl fumarate; Monoethanolamine; Ferric oxide red; Ferric oxide yellow; Propylene glycol; Talc; Titanium dioxide; Triethyl citrate; Carnauba wax; Hypromelloses
                   Dosage Form Delayed Release Oral Tablet
                   Company Aldi; Humana Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Hydroxyethylamine DIG Info Lipid transfer protein I (IC50 = 600 nM) [14]
Sodium stearate DIG Info Free fatty acid receptor 4 (EC50 = 1698.24 nM) [15]
Sodium lauryl sulfate DIG Info Solute carrier SLCO2B1 (Ki = 1.98 uM) [3]
Sodium stearyl fumarate DIG Info Leukemia K562 cells (IC50 = 20.2 ug.mL-1) [12]
Propylene glycol DIG Info Albendazole monooxygenase (Inhibition ratio < 20 %) [7]
          Esomeprazole 49.3 mg capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Fd&c red no. 40; Fd&c blue no. 1; Fd&c yellow no. 6; Glyceryl monostearate; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hypromelloses; Methacrylic acid; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Amneal Pharmaceuticals; ParaPRO
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Fd&c red no. 40; Fd&c blue no. 1; Fd&c yellow no. 6; Glyceryl monostearate; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hypromelloses; Methacrylic acid; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company R2 Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 4.7 uM) [2]
FD&C blue no. 1 DIG Info Solute carrier SLCO2B1 (Ki = 13 uM) [3]
Sunset yellow FCF DIG Info Solute carrier SLCO2B1 (Ki = 68.4 uM) [3]
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
Allura red AC dye DIG Info Solute carrier SLCO2B1 (Ki = 2.59 uM) [3]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
          Esomeprazole 24.65 mg capsule Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Glyceryl monostearate; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hypromelloses; Methacrylic acid; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company Amneal Pharmaceuticals; ParaPRO
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Calcium carbonate; Glyceryl monostearate; Ferric oxide red; Sucrose; Talc; Titanium dioxide; Triethyl citrate; Polysorbate 80; Gelatin; Hypromelloses; Methacrylic acid; Starch, corn
                   Dosage Form Delayed Release Oral Capsule
                   Company R2 Pharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Calcium carbonate DIG Info Carbonic anhydrase IX (Ki = 8600 nM) [13]
Glyceryl monostearate DIG Info Prostate cancer LNCaP cells (IC50 > 100000 nM) [6]
Polysorbate 80 DIG Info Prostaglandin G/H synthase 1 (IC50 = 1 uM) [2]
References
1 FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.
4 Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Bioorg Med Chem. 2012 Jan 15; 20(2):641-9.
5 Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
6 Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds. J Nat Prod. 2002 Feb; 65(2):206-9.
7 Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.
8 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
9 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.
10 PubChem BioAssay data set.
11 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19; 14(8):1923-6.
12 Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents. Eur J Med Chem. 2014 Apr 9; 76:291-300.
13 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):567-71.
14 Some molecular targets for antihyperlipidemic drug research. Eur J Med Chem. 2014 Oct 6; 85:535-68.
15 Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. Med Chem Comm. 2017; 8:1360-1365.
16 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.