Details of the Drug Formulation (DFM)
General Information of DFM (ID: F23618) | |||||
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Name |
Amcinonide 0.1% ointment
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Company |
Astellas
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Active Pharmaceutical Ingredient (API) | Amcinonide | API Info click to show the detail info of this API | |||
Approved | |||||
Drug Inactive Ingredient (DIGs) | |||||
DIG ID | DIG Info | DIG Name | DIG Functional Class | ||
E0NY1O | DIG Info | Benzyl alcohol | Antimicrobial preservative ... | ||
E0QV6C | DIG Info | Butylhydroxyanisole | Antimicrobial preservative ... | ||
E0F6AN | DIG Info | Kyselina citronova | Acidulant ... | ||
E0U9NK | DIG Info | Propyl gallate | Antimicrobial preservative ... | ||
E0M1JK | DIG Info | Propylene glycol | Antimicrobial preservative ... | ||
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM | ||||||
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G-protein coupled receptor (GPCR) | ||||||
DBT Name: Muscarinic receptor M1 (ACM1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Butylhydroxyanisole | |||||
Biological Activity | IC50 = 19 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ACM1_HUMAN | |||||
DBT Name: Alpha-1A adrenoceptor (ADA1A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Butylhydroxyanisole | |||||
Biological Activity | IC50 = 19 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ADA1A_HUMAN | |||||
Oxidoreductase (ORase) | ||||||
DBT Name: N1-methyl adenine demethylase (FTO) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 300000 nM (tested by experiment) | [2] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | FTO_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 3 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | FTO_HUMAN | |||||
DBT Name: Arachidonate 5-lipoxygenase (ALOX5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 0.43 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | LOX5_HUMAN | |||||
DBT Name: Indoleamine 2,3-dioxygenase 1 (IDO1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Benzyl alcohol | |||||
Biological Activity | IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 ) | [3] | ||||
Structural Similarity | Tanimoto coefficient = 0.848101266 | |||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | I23O1_HUMAN | |||||
DBT Name: Prostaglandin G/H synthase 2 (COX-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment (1) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | IC50 = 7.2 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PGH2_HUMAN | |||||
Experiment (2) for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Butylhydroxyanisole | |||||
Biological Activity | IC50 = 2.6 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PGH2_HUMAN | |||||
DBT Name: RNA demethylase ALKBH5 (ALKB5) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 488000 nM (tested by experiment) | [4] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ALKB5_HUMAN | |||||
DBT Name: Lysine-specific demethylase 4C (KDM4C) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 39 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | KDM4C_HUMAN | |||||
DBT Name: Tyrosine 3-monooxygenase (TH) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 1.9 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | TY3H_HUMAN | |||||
DBT Name: Albendazole monooxygenase (CYP3A4) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propylene glycol | |||||
Biological Activity | Inhibition ratio < 20 % (tested by experiment) | [5] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | CP3A4_HUMAN | |||||
Cation-dependent O-methyltransferase | ||||||
DBT Name: Catechol O-methyltransferase (COMT) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Ki = 0.015 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | COMT_HUMAN | |||||
Hydrolase (HDase) | ||||||
DBT Name: Phosphodiesterase 4D (PDE4D) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | IC50 = 26 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PDE4D_HUMAN | |||||
Potential-driven transporter (PDT) | ||||||
DBT Name: Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | Inhibition ratio = 29.6 % (tested by experiment) | [6] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | SO2B1_HUMAN | |||||
Nuclear receptor (NR) | ||||||
DBT Name: Factor HNF-4-alpha (HNF4A) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 39869 nM (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | HNF4A_HUMAN | |||||
DBT Name: Progesterone receptor (PGR) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Butylhydroxyanisole | |||||
Biological Activity | IC50 = 29 uM (tested by experiment) | [1] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PRGR_HUMAN | |||||
Other protein families (OPF) | ||||||
DBT Name: Anthrax toxin receptor 2 (CMG-2) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Propyl gallate | |||||
Biological Activity | IC50 > 300000 nM (tested by experiment) | [8] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | ANTR2_HUMAN | |||||
DBT Name: Perilipin-1 (PLIN1) | Click to Show/Hide | |||||
Detailed Information | DBT Info click to show the detail info of this DBT | |||||
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT | ||||||
Interacting DIG | Kyselina citronova | |||||
Biological Activity | IC50 = 3708 nM (tested by experiment) | [7] | ||||
Tested Species | Homo sapiens (Human) | |||||
UniProt ID | PLIN1_HUMAN | |||||
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